Goel Harsh, Kumar Rahul, Tanwar Pranay, Upadhyay Tarun Kumar, Khan Fahad, Pandey Pratibha, Kang Sojin, Moon Myunghan, Choi Jinwon, Choi Min, Park Moon Nyeo, Kim Bonglee, Saeed Mohd
Department of Laboratory Oncology, All India Institute of Medical Sciences, New Delhi 11023, India.
Department of Biotechnology, Parul Institute of Applied Sciences and Centre of Research for Development, Parul University, Vadodara 391760, India,.
Biomed Pharmacother. 2023 Apr;160:114351. doi: 10.1016/j.biopha.2023.114351. Epub 2023 Feb 1.
Leukemia is a heterogeneous group of hematological malignancies distinguished by differentiation blockage and uncontrolled proliferation of myeloid or lymphoid progenitor cells in the bone marrow (BM) and peripheral blood (PB). There are various types of leukemia in which intensive chemotherapy regimens or hematopoietic stem cell transplantation (HSCT) are now the most common treatments associated with severe side effects and multi-drug resistance in leukemia cells. Therefore, it is crucial to develop novel therapeutic approaches with adequate therapeutic efficacy and selectively eliminate leukemic cells to improve the consequences of leukemia. Medicinal plants have been utilized for ages to treat multiple disorders due to their diverse bioactive compounds. Plant-derived products have been used as therapeutic medication to prevent and treat many types of cancer. Over the last two decades, 50 % of all anticancer drugs approved worldwide are from natural products and their derivatives. Therefore this study aims to review natural products such as polyphenols, alkaloids, terpenoids, nitrogen-containing, and organosulfur compounds as antileukemic agents. Current investigations have identified natural products efficiently destroy leukemia cells through diverse mechanisms of action by inhibiting proliferation, reactive oxygen species production, inducing cell cycle arrest, and apoptosis in both in vitro, in vivo, and clinical studies. Current investigations have identified natural products as suitable promising chemotherapeutic and chemopreventive agents. It played an essential role in drug development and emerged as a possible source of biologically active metabolites for therapeutic interventions, especially in leukemia. DATA AVAILABILITY: Data will be made available on request.
白血病是一组异质性血液系统恶性肿瘤，其特征为骨髓（BM）和外周血（PB）中髓系或淋巴系祖细胞的分化阻滞和不受控制的增殖。白血病有多种类型，目前强化化疗方案或造血干细胞移植（HSCT）是最常见的治疗方法，但这些方法会带来严重的副作用，且白血病细胞存在多药耐药性。因此，开发具有足够治疗效果并能选择性消除白血病细胞的新型治疗方法对于改善白血病的治疗结果至关重要。药用植物因其多样的生物活性化合物，长期以来一直被用于治疗多种疾病。植物衍生产品已被用作治疗药物来预防和治疗多种癌症。在过去二十年中，全球批准的所有抗癌药物中有50%来自天然产物及其衍生物。因此，本研究旨在综述多酚、生物碱、萜类、含氮化合物和有机硫化合物等天然产物作为抗白血病药物的情况。目前的研究已确定，在体外、体内和临床研究中，天然产物通过抑制增殖、产生活性氧、诱导细胞周期阻滞和凋亡等多种作用机制有效地破坏白血病细胞。目前的研究已确定天然产物是合适的、有前景的化疗和化学预防药物。它在药物开发中发挥了重要作用，并成为治疗干预，尤其是白血病治疗中生物活性代谢物的一个可能来源。数据可用性：数据将根据要求提供。
