超级增强子长链非编码 RNA：癌症的一个新标志。
Super enhancer lncRNAs: a novel hallmark in cancer.
机构信息
Department of Gastroenterology, Affiliated Hangzhou First People's Hospital, Westlake University, Hangzhou, 310006, Zhejiang Province, China.
Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Hangzhou, 310006, China.
出版信息
Cell Commun Signal. 2024 Apr 2;22(1):207. doi: 10.1186/s12964-024-01599-6.
Super enhancers (SEs) consist of clusters of enhancers, harboring an unusually high density of transcription factors, mediator coactivators and epigenetic modifications. SEs play a crucial role in the maintenance of cancer cell identity and promoting oncogenic transcription. Super enhancer lncRNAs (SE-lncRNAs) refer to either transcript from SEs locus or interact with SEs, whose transcriptional activity is highly dependent on SEs. Moreover, these SE-lncRNAs can interact with their associated enhancer regions in cis and modulate the expression of oncogenes or key signal pathways in cancers. Inhibition of SEs would be a promising therapy for cancer. In this review, we summarize the research of SE-lncRNAs in different kinds of cancers so far and decode the mechanism of SE-lncRNAs in carcinogenesis to provide novel ideas for the cancer therapy.
超级增强子 (SEs) 由簇状增强子组成，含有异常高密度的转录因子、中介共激活因子和表观遗传修饰。SEs 在维持癌细胞身份和促进致癌转录中起着至关重要的作用。超级增强子长非编码 RNA (SE-lncRNA) 是指来自 SE 基因座的转录本或与 SE 相互作用的转录本，其转录活性高度依赖于 SE。此外，这些 SE-lncRNA 可以与顺式相互作用的相关增强子区域相互作用，并调节癌症中癌基因或关键信号通路的表达。抑制 SE 将是癌症治疗的一种有前途的方法。在这篇综述中，我们总结了迄今为止不同类型癌症中 SE-lncRNA 的研究，并解码了 SE-lncRNA 在致癌作用中的机制，为癌症治疗提供了新的思路。
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