Rosa Maria Inês, Grande Antonio José, Lima Leticia Dorsa, Dondossola Eduardo Ronconi, Uggioni Maria Laura Rodrigues, Hernandez Adrian V, Tse Gary, Liu Tong, Pontes-Neto Octávio Marques, Biondi-Zoccai Giuseppe, Neto Mansueto Gomes, Durães André Rodrigues, Sá Michel Pompeu B O, Resende Elmiro Santos, Roever Leonardo
Laboratory of Biomedicine Translational, University of Extremo Sul Catarinense, Criciúma, Brazil.
Department of Medicine, State University of Mato Grosso Do Sul, Mato Grosso, Brazil.
Front Cardiovasc Med. 2021 Apr 21;8:658445. doi: 10.3389/fcvm.2021.658445. eCollection 2021.
Epicardial adipose tissue (EAT) is correlated with endothelial dysfunction, metabolic syndrome, increased mortality and recent studies showed a possible association with the increased risk of stroke. We performed a systematic review of studies evaluating the association between EAT and stroke. Eighty studies met the inclusion criteria and were consequently analyzed. The review had Five main findings. First, the increased epicardial fat thickness (EFT) may be associated with the stroke episode. Second, regardless of the imaging method (echocardiography, MRI, and CT) this association remains. Third, the association of metabolic syndrome and atrial fibrillation seems to increase the risk of stroke. Fourth, this systematic review was considered as low risk of bias. Despite being unable to establish a clear association between EAT and stroke, we have organized and assessed all the research papers on this topic, analyzing their limitations, suggesting improvements in future pieces of research and pointing out gaps in the literature. Furthermore, the mechanistic links between increased EAT and stroke incidence remains unclear, thus, further research is warranted.
心外膜脂肪组织（EAT）与内皮功能障碍、代谢综合征、死亡率增加相关，并且最近的研究表明其与中风风险增加可能存在关联。我们对评估EAT与中风之间关联的研究进行了系统综述。80项研究符合纳入标准并因此进行了分析。该综述有五项主要发现。第一，心外膜脂肪厚度（EFT）增加可能与中风发作有关。第二，无论成像方法（超声心动图、MRI和CT）如何，这种关联都存在。第三，代谢综合征和心房颤动的关联似乎会增加中风风险。第四，该系统综述被认为偏倚风险较低。尽管无法确定EAT与中风之间存在明确关联，但我们整理并评估了关于该主题的所有研究论文，分析了它们的局限性，为未来的研究提出了改进建议，并指出了文献中的空白。此外，EAT增加与中风发生率之间的机制联系仍不清楚，因此，有必要进一步研究。
