Mi Jie, Liu Chao, Chen Honglei, Qian Yan, Zhu Jingyi, Zhang Yachao, Liang Yizhi, Wang Lidai, Ta Dean
Yiwu Research Institute, Fudan University, Yiwu, China.
Digital Medical Research Center, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Front Aging Neurosci. 2024 Mar 18;16:1363458. doi: 10.3389/fnagi.2024.1363458. eCollection 2024.
Alzheimer's disease (AD), referring to a gradual deterioration in cognitive function, including memory loss and impaired thinking skills, has emerged as a substantial worldwide challenge with profound social and economic implications. As the prevalence of AD continues to rise and the population ages, there is an imperative demand for innovative imaging techniques to help improve our understanding of these complex conditions. Photoacoustic (PA) imaging forms a hybrid imaging modality by integrating the high-contrast of optical imaging and deep-penetration of ultrasound imaging. PA imaging enables the visualization and characterization of tissue structures and multifunctional information at high resolution and, has demonstrated promising preliminary results in the study and diagnosis of AD. This review endeavors to offer a thorough overview of the current applications and potential of PA imaging on AD diagnosis and treatment. Firstly, the structural, functional, molecular parameter changes associated with AD-related brain imaging captured by PA imaging will be summarized, shaping the diagnostic standpoint of this review. Then, the therapeutic methods aimed at AD is discussed further. Lastly, the potential solutions and clinical applications to expand the extent of PA imaging into deeper AD scenarios is proposed. While certain aspects might not be fully covered, this mini-review provides valuable insights into AD diagnosis and treatment through the utilization of innovative tissue photothermal effects. We hope that it will spark further exploration in this field, fostering improved and earlier theranostics for AD.
阿尔茨海默病（AD）是指认知功能逐渐衰退，包括记忆力丧失和思维能力受损，已成为一项具有重大社会和经济影响的全球性挑战。随着AD患病率持续上升以及人口老龄化，迫切需要创新的成像技术来帮助我们更好地理解这些复杂病症。光声（PA）成像通过整合光学成像的高对比度和超声成像的深层穿透能力，形成了一种混合成像模式。PA成像能够在高分辨率下可视化组织结构并表征多功能信息，并且在AD的研究和诊断中已显示出有前景的初步结果。本综述旨在全面概述PA成像在AD诊断和治疗方面的当前应用及潜力。首先，将总结PA成像所捕捉到的与AD相关脑成像有关的结构、功能、分子参数变化，以此形成本综述的诊断观点。然后，进一步讨论针对AD的治疗方法。最后，提出了潜在的解决方案和临床应用，以将PA成像扩展到更深入的AD场景中。虽然某些方面可能未被全面涵盖，但本小型综述通过利用创新的组织光热效应，为AD的诊断和治疗提供了有价值的见解。我们希望它能激发该领域的进一步探索，促进AD诊断与治疗的改善和早期实施。
