Bertola Adeline, Gallerand Alexandre, Ivanov Stoyan
Université Côte d'Azur, CNRS, LP2M, Nice, France.
Discov Immunol. 2022 Oct 31;1(1):kyac007. doi: 10.1093/discim/kyac007. eCollection 2022.
Brown adipose tissue (BAT) contains many immune cells. The presence of macrophages, monocytes, dendritic cells, T cells, B cells, and mast cells was documented in BAT. However, in comparison to white adipose tissue, relatively little is known on the impact of immune cells on BAT function. By directly interacting with BAT stromal cells, or by secreting pro- and anti-inflammatory mediators, immune cells modulate BAT activation and subsequently influence on adaptative thermogenesis and heat generation. In the current manuscript, we will focus on the diversity and functions of BAT immune cells.
棕色脂肪组织（BAT）含有许多免疫细胞。巨噬细胞、单核细胞、树突状细胞、T细胞、B细胞和肥大细胞在BAT中的存在已得到证实。然而，与白色脂肪组织相比，关于免疫细胞对BAT功能的影响，我们所知相对较少。通过直接与BAT基质细胞相互作用，或通过分泌促炎和抗炎介质，免疫细胞调节BAT的激活，进而影响适应性产热和热量生成。在本手稿中，我们将聚焦于BAT免疫细胞的多样性和功能。
