Zhou Shujing, Liu Ying, Huang Xufeng, Wu Chuhan, Pórszász Róbert
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Department of Cardiology, Sixth Medical Centre, Chinese PLA General Hospital, Beijing, China.
Front Cardiovasc Med. 2024 Mar 19;11:1337154. doi: 10.3389/fcvm.2024.1337154. eCollection 2024.
Heart failure, a prevailing global health issue, imposes a substantial burden on both healthcare systems and patients worldwide. With an escalating prevalence of heart failure, prolonged survival rates, and an aging demographic, an increasing number of individuals are progressing to more advanced phases of this incapacitating ailment. Against this backdrop, the quest for pharmacological agents capable of addressing the diverse subtypes of heart failure becomes a paramount pursuit. From this viewpoint, the present article focuses on Omecamtiv Mecarbil (OM), an emerging chemical compound said to exert inotropic effects without altering calcium homeostasis. For the first time, as a review, the present article uniquely started from the very basic pathophysiology of heart failure, its classification, and the strategies underpinning drug design, to on-going debates of OM's underlying mechanism of action and the latest large-scale clinical trials. Furthermore, we not only saw the advantages of OM, but also exhaustively summarized the concerns in sense of its effects. These of no doubt make the present article the most systemic and informative one among the existing literature. Overall, by offering new mechanistic insights and therapeutic possibilities, OM has carved a significant niche in the treatment of heart failure, making it a compelling subject of study.
心力衰竭是一个普遍存在的全球健康问题，给全球的医疗系统和患者都带来了沉重负担。随着心力衰竭患病率的不断上升、生存率的延长以及人口老龄化，越来越多的人正步入这种使人衰弱疾病的更晚期阶段。在此背景下，寻找能够应对不同亚型心力衰竭的药物成为了首要追求。从这个角度来看，本文聚焦于奥米卡替麦卡比（OM），一种据称能发挥正性肌力作用而不改变钙稳态的新型化合物。作为一篇综述，本文首次从心力衰竭最基本的病理生理学、其分类以及药物设计的基础策略出发，到关于OM作用机制的持续争论以及最新的大规模临床试验。此外，我们不仅看到了OM的优势，还详尽总结了其在效应方面的相关问题。这些无疑使本文成为现有文献中最具系统性和信息量的一篇。总体而言，通过提供新的机制见解和治疗可能性，OM在心力衰竭治疗中占据了重要地位，使其成为一个引人注目的研究对象。
