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白藜芦醇促进自我消化以使癌症休眠。

Resveratrol Promotes Self-digestion to Put Cancer to Sleep.

作者信息

Ferraresi Alessandra, Thongchot Suyanee, Isidoro Ciro

机构信息

Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale, Novara, Italy.

出版信息

J Cancer Prev. 2024 Mar 30;29(1):1-5. doi: 10.15430/JCP.24.001. Epub 2024 Mar 29.

DOI:10.15430/JCP.24.001
PMID:38567110
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10982519/
Abstract

Resveratrol, a natural polyphenol present in a variety of food stuff, has been shown to exert preventive and curative anticancer activity in several in vitro and in vivo models. Such chemopreventive/anticancer activity has been linked to biochemical and epigenetic modifications of multiple pathways involved in carcinogenesis and metastasization. In this commentary, we focus on the recent work done in our laboratory showing that resveratrol has potential to prevent and cure cancer by promoting epigenetic-mediated autophagy-dependent tumor dormancy, an effect associated with re-education of the cancer-associated fibroblasts and reduced production of inflammatory cytokines in the tumor microenvironment. The clinical translation of the current knowledge on resveratrol anticancer activity is also discussed.

摘要

白藜芦醇是一种存在于多种食物中的天然多酚，已在多种体外和体内模型中显示出具有预防和治疗癌症的活性。这种化学预防/抗癌活性与致癌和转移过程中多个途径的生化和表观遗传修饰有关。在这篇评论中，我们重点关注我们实验室最近的研究工作，该研究表明白藜芦醇有潜力通过促进表观遗传介导的自噬依赖性肿瘤休眠来预防和治疗癌症，这种效应与癌症相关成纤维细胞的重塑以及肿瘤微环境中炎性细胞因子产生的减少有关。我们还讨论了目前关于白藜芦醇抗癌活性知识的临床转化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e019/10982519/8c4c1f24e27c/jcp-29-1-1-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e019/10982519/00574439c49f/jcp-29-1-1-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e019/10982519/8c4c1f24e27c/jcp-29-1-1-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e019/10982519/00574439c49f/jcp-29-1-1-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e019/10982519/8c4c1f24e27c/jcp-29-1-1-f2.jpg

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Glycolysis Inhibition of Autophagy Drives Malignancy in Ovarian Cancer: Exacerbation by IL-6 and Attenuation by Resveratrol.
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