Department of Biological Sciences, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai 600 077, Tamil Nadu, India.
Int J Mol Sci. 2022 Oct 3;23(19):11712. doi: 10.3390/ijms231911712.
Human diseases such as cancer can be caused by aberrant epigenetic regulation. Polyphenols play a major role in mammalian epigenome regulation through mechanisms and proteins that remodel chromatin. In fruits, seeds, and vegetables, as well as food supplements, polyphenols are found. Compounds such as these ones are powerful anticancer agents and antioxidants. Gallic acid, kaempferol, curcumin, quercetin, and resveratrol, among others, have potent anti-tumor effects by helping reverse epigenetic changes associated with oncogene activation and tumor suppressor gene inactivation. The role dietary polyphenols plays in restoring epigenetic alterations in cancer cells with a particular focus on DNA methylation and histone modifications was summarized. We also discussed how these natural compounds modulate gene expression at the epigenetic level and described their molecular targets in cancer. It highlights the potential of polyphenols as an alternative therapeutic approach in cancer since they modulate epigenetic activity.
人类疾病（如癌症）可能是由异常的表观遗传调控引起的。多酚通过重塑染色质的机制和蛋白质在哺乳动物表观基因组调控中发挥主要作用。多酚存在于水果、种子和蔬菜以及食品补充剂中。这些化合物是强大的抗癌和抗氧化剂。没食子酸、山柰酚、姜黄素、槲皮素和白藜芦醇等通过帮助逆转与癌基因激活和肿瘤抑制基因失活相关的表观遗传变化，具有很强的抗肿瘤作用。本文总结了膳食多酚在恢复癌细胞表观遗传改变方面的作用，特别关注 DNA 甲基化和组蛋白修饰。我们还讨论了这些天然化合物如何在表观遗传水平上调节基因表达，并描述了它们在癌症中的分子靶点。这凸显了多酚作为一种癌症治疗方法的潜力，因为它们可以调节表观遗传活性。
