Liu Fa-Sheng, Huang Hua-Liang
Department of Laboratory, Inner Mongolia Baogang Hospital, Baotou, China.
Front Oncol. 2024 Mar 19;14:1341840. doi: 10.3389/fonc.2024.1341840. eCollection 2024.
Acute promyelocytic leukemia (APL) is a type of acute myeloid leukemia. About 2% of APL is characterized by atypical rearrangements. Here we reported one APL case with atypical manifestations and morphology. A 35-year-old woman patient, mainly due to fatigue, poor appetite for over 10 days and intermittent fever for 3 days. combined with the results of flow cytometry, fusion gene and chromosome, the patient was diagnosed as AML-M3 with atypical morphology. Double induction therapy with retinoic acid and arsenous acid was immediately administrated. Idarubicin was administrated on the 18th day. A re-examination was performed in the 5th week, both the blood routine test and myelogram showed normal results, and the fusion gene turned negative, indicating complete remission. When atypical morphology occurs, peripheral blood POX staining may be performed to check the abnormal cells. Flow cytometry, chromosome analysis, and fusion gene analysis are also required for further diagnosis.
急性早幼粒细胞白血病（APL）是急性髓系白血病的一种类型。约2%的APL具有非典型重排特征。在此我们报告1例具有非典型表现和形态学特征的APL病例。一名35岁女性患者，主要因乏力、食欲减退10余天，间断发热3天。结合流式细胞术、融合基因及染色体结果，该患者被诊断为具有非典型形态学特征的AML-M3。立即给予维甲酸和亚砷酸双诱导治疗。第18天给予去甲氧柔红霉素。第5周进行复查，血常规和骨髓象检查结果均正常，融合基因转为阴性，提示完全缓解。当出现非典型形态学时，可进行外周血POX染色以检查异常细胞。进一步诊断还需要流式细胞术、染色体分析及融合基因分析。
