Tajammul Syeda Sara, Rassou Salim Chaib, Munir Javeria, Ahmed Zubair, Nadaf Asma Naaz
Radiation Oncology, Sultan Qaboos Comprehensive Cancer Care and Research Centre (SQCCCRC), Muscat, OMN.
Radiology, Sultan Qaboos Comprehensive Cancer Care and Research Centre (SQCCCRC), Muscat, OMN.
Cureus. 2024 Mar 3;16(3):e55427. doi: 10.7759/cureus.55427. eCollection 2024 Mar.
Primary intracranial meningeal melanomas are rare. Diagnosing primary meningeal melanomas mostly involves comprehensive assessment through clinical and radiological means. This evaluation should encompass a detailed dermal and ophthalmic examination. Any suspicious lesion must be biopsied and examined microscopically. This is crucial not only to differentiate primary intracranial melanoma from other brain tumors but also to rule out metastases from potential sources of primary cutaneous or non-cutaneous melanomas. Surgery is considered the mainstay of treatment. Despite melanomas being generally considered radio- and chemo-resistant tumors, adjuvant radiotherapy and chemotherapy still play a crucial role in their management. The treatment landscape for primary meningeal melanoma is continually evolving, with ongoing research aiming to improve outcomes for patients with this challenging disease.
原发性颅内脑膜黑色素瘤很罕见。诊断原发性脑膜黑色素瘤主要通过临床和影像学手段进行综合评估。这种评估应包括详细的皮肤和眼科检查。任何可疑病变都必须进行活检并进行显微镜检查。这不仅对于区分原发性颅内黑色素瘤与其他脑肿瘤至关重要,而且对于排除原发性皮肤或非皮肤黑色素瘤潜在来源的转移也很关键。手术被认为是主要的治疗方法。尽管黑色素瘤通常被认为是对放疗和化疗耐药的肿瘤,但辅助放疗和化疗在其治疗中仍起着关键作用。原发性脑膜黑色素瘤的治疗格局在不断演变,正在进行的研究旨在改善患有这种具有挑战性疾病的患者的治疗效果。