Chen Chao, Lu Zhiqin, Lin Gang, Hu Yujie, Guo Yong
The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China.
Department of Radiotherapy, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, China.
Front Oncol. 2025 Jun 19;15:1613711. doi: 10.3389/fonc.2025.1613711. eCollection 2025.
Meckel's cave (MC) is a highly uncommon site for metastatic disease, particularly from primary lung cancer.
We report a clinical case of a 70-year-old man presenting with left trigeminal pain, left ptosis, and restricted abduction of the left eyeball. The patient had a 2-year history of stage IV lung squamous cell carcinoma. Contrast-enhanced brain MRI and FDG-PET/CT showed an ill-defined mass with a heterogeneously enhancing lesion involving the left MC and middle cranial fossa. Stereotactic radiosurgery (SRS, 30 Gy/5 fx) achieved significant improvement in symptoms and regression of radiologic tumors within 1 month. Our review of relevant literature identified only two reported cases of lung adenocarcinoma metastasizing to MC. In addition, we examined the limited literature on other malignant tumors metastatic to MC managed with radiotherapy.
This is the first reported case of MC metastasis from lung squamous cell carcinoma successfully treated with SRS. Effective management of MC metastasis requires histology-specific radiotherapy strategies, with squamous cell carcinoma benefiting from hypofractionated SRS.
梅克尔腔（MC）是转移性疾病极为罕见的发病部位，尤其是原发性肺癌转移至此。
我们报告一例70岁男性临床病例，该患者表现为左侧三叉神经痛、左侧上睑下垂及左侧眼球外展受限。患者有IV期肺鳞状细胞癌病史2年。对比增强脑MRI及FDG-PET/CT显示左侧MC及中颅窝有一界限不清的肿块，伴有不均匀强化病灶。立体定向放射外科治疗（SRS，30 Gy/5次分割）在1个月内使症状显著改善，影像学肿瘤消退。我们对相关文献的回顾仅发现两例肺腺癌转移至MC的报道病例。此外，我们查阅了关于其他转移至MC的恶性肿瘤接受放疗的有限文献。
这是首例成功采用SRS治疗肺鳞状细胞癌转移至MC的报道病例。MC转移的有效管理需要组织学特异性放疗策略，鳞状细胞癌受益于低分割SRS。
