Liu Linlin, Wang Xiufen, Luo Li, Liu Xuhui, Chen Jingfang
Hengyang Medical School, School of Nursing, University of South China, Hengyang, People's Republic of China.
Department of the Third Pulmonary Disease, The Third People's Hospital of Shenzhen, Shenzhen, People's Republic of China.
Risk Manag Healthc Policy. 2024 Mar 28;17:753-762. doi: 10.2147/RMHP.S448765. eCollection 2024.
Tuberculosis destroyed lung constitutes a significant worldwide public health challenge, little is known about its associated risk factors and prognosis. Our study aimed to identify the risk factors of tuberculosis destroyed lung among pulmonary tuberculosis and structural lung diseases.
Between January 2019 and December 2021, a case-control study was conducted at the Third People's Hospital of Shenzhen in China. We collected the clinical data among patients with pulmonary tuberculosis and structural lung diseases. Cases were defined as patients with tuberculosis destroyed lung. Controls were not diagnosed with the tuberculosis destroyed lung. A binary logistic regression was performed.
In our study, a total of 341 patients met the inclusion criteria, including 182 cases and 159 controls. We found that age ranges of 46-60 years (aOR: 4.879; 95% CI: 2.338-10.180), >60 years (aOR: 3.384; 95% CI: 1.481-7.735); history of TB treatment (aOR: 2.729; 95% CI: 1.606-4.638); malnutrition (aOR: 5.126; 95% CI: 1.359-19.335); respiratory failure (aOR: 5.080; 95% CI: 1.491-17.306); and bronchiarctia (aOR: 3.499; 95% CI: 1.330-9.209) were the independent risk factors for tuberculosis destroyed lung. Conversely, having a normal (aOR: 0.207; 95% CI: 0.116-0.371) or overweight BMI (aOR: 0.259; 95% CI: 0.090-0.747) emerged as a protective factor against tuberculosis destroyed lung.
This study indicated that tuberculosis destroyed lung is a common condition among patients with pulmonary tuberculosis and structural lung diseases. The independent risk factors for tuberculosis destroyed lung were identified as being within the age groups of 46-60 and over 60 years, having a previous history of TB treatment, malnutrition, respiratory failure, and bronchiarctia. It is essential to closely monitor patients possessing these risk factors to prevent the progression towards tuberculosis destroyed lung.
结核毁损肺是一项重大的全球性公共卫生挑战，人们对其相关危险因素和预后知之甚少。我们的研究旨在确定肺结核和结构性肺病患者中结核毁损肺的危险因素。
2019年1月至2021年12月期间，在中国深圳市第三人民医院进行了一项病例对照研究。我们收集了肺结核和结构性肺病患者的临床资料。病例定义为患有结核毁损肺的患者。对照为未被诊断为结核毁损肺的患者。进行了二元逻辑回归分析。
在我们的研究中，共有341名患者符合纳入标准，包括182例病例和159名对照。我们发现年龄在46 - 60岁（调整后比值比：4.879；95%置信区间：2.338 - 10.180）、>60岁（调整后比值比：3.384；95%置信区间：1.481 - 7.735）；有结核病治疗史（调整后比值比：2.729；95%置信区间：1.606 - 4.638）；营养不良（调整后比值比：5.126；95%置信区间：1.359 - 19.335）；呼吸衰竭（调整后比值比：5.080；95%置信区间：1.491 - 17.306）；以及支气管狭窄（调整后比值比：3.499；95%置信区间：1.330 - 9.209）是结核毁损肺的独立危险因素。相反，体重指数正常（调整后比值比：0.207；95%置信区间：0.116 - 0.371）或超重（调整后比值比：0.259；95%置信区间：0.090 - 0.747）是预防结核毁损肺的保护因素。
本研究表明，结核毁损肺在肺结核和结构性肺病患者中是一种常见情况。结核毁损肺的独立危险因素被确定为年龄在46 - 60岁和60岁以上、有结核病治疗史、营养不良、呼吸衰竭和支气管狭窄。密切监测具有这些危险因素的患者以防止进展为结核毁损肺至关重要。
