Department of Biomedical Sciences, University of Wyoming, Laramie, WY, USA.
Reproductive Biology and Toxicology Research Laboratory, Oasis of Grace Hospital, Osogbo, Nigeria.
Aging Male. 2024 Dec;27(1):2336627. doi: 10.1080/13685538.2024.2336627. Epub 2024 Apr 3.
Penile erection (PE) is a hemodynamic event that results from a neuroendocrine process, and it is influenced by the cardiovascular status of the patient. However, it may also modulate an individual's cardiovascular events. The present study provides the mechanisms involved in the association of PE and cardiovascular function. Erection upsurges the cardiac rate, blood pressure, and oxygen uptake. Sex-enhancing strategies, such as phosphodiesterase inhibitors, alprostadil, and testosterone also promote vasodilatation and cardiac performance, thus preventing myocardial infarction. More so, drugs that are used in the treatment of hypertensive heart diseases (such as angiotensin system inhibitors and β-blockers) facilitate vasodilatation and PE. These associations have been linked with nitric oxide- and testosterone-dependent enhancing effects on the vascular endothelium. In addition, impaired cardiovascular function may negatively impact PE; therefore, impaired PE may be a pointer to cardiovascular pathology. Hence, evaluation of the cardiovascular status of an individual with erectile dysfunction (ED) is essential. Also, employing strategies that are used in maintaining optimal cardiac function may be useful in the management of ED.
阴茎勃起（PE）是一种血液动力学事件，源自神经内分泌过程，受患者心血管状况的影响。然而，它也可能调节个体的心血管事件。本研究提供了与 PE 和心血管功能相关的机制。勃起会增加心率、血压和耗氧量。增强性功能的策略，如磷酸二酯酶抑制剂、前列地尔和睾酮，也促进血管扩张和心脏功能，从而预防心肌梗死。更重要的是，用于治疗高血压性心脏病的药物（如血管紧张素系统抑制剂和β受体阻滞剂）促进血管扩张和 PE。这些关联与血管内皮的一氧化氮和睾酮依赖性增强作用有关。此外，心血管功能受损可能对 PE 产生负面影响；因此，PE 受损可能是心血管病理的一个指标。因此，评估勃起功能障碍（ED）患者的心血管状况至关重要。此外，采用维持最佳心脏功能的策略可能对 ED 的治疗有用。
