Tamrakar Arpna, Wani Manzoor Ahmad, Mishra Gargi, Srivastava Ankur, Pandey Rampal, Pandey Mrituanjay D
Department of Chemistry, Institute of Science, Banaras Hindu University, UP-221005, India.
Department of Chemistry, National Institute of Technology Uttarakhand, UK-246174, India.
Anal Methods. 2024 Apr 18;16(15):2198-2228. doi: 10.1039/d3ay02321d.
The CN bond isomerization/modulation as a fluorescence signalling mechanism was explored by studying the photophysical properties of conformationally restricted molecules. From the beginning, the CN bond isomerization method has attracted the attention of researchers owing to its simplicity, high selectivity, and sensitivity in fluorescence evaluation. Continuous developments in the field of sensing using CN bond-containing compounds have been achieved the customization of the isomerization process around the CN bond in numerous ways, and the results were obtained in the form of specific discrete photophysical changes. CN isomerization causes significant fluorescence enhancement in response to detected metal cations and other reactive species (Cys, Hys, ClO, ) straightforwardly and effectively. This review sheds light on the process of CN bond isomerization/modulation as a signalling mechanism depending on fluorescence changes conformational restriction. In addition, CN bond isomerization-based fluorescent sensors have yet to be well reviewed, although several fluorescent sensors based on this signalling mechanism have been reported. Therefore, CN-based fluorescent sensors are summarized in this review.
通过研究构象受限分子的光物理性质，探索了C=N键异构化/调制作为一种荧光信号机制。从一开始，C=N键异构化方法就因其在荧光评估中的简单性、高选择性和灵敏度而吸引了研究人员的关注。在使用含C=N键化合物的传感领域已经取得了持续的进展——通过多种方式对C=N键周围的异构化过程进行定制，并以特定的离散光物理变化的形式获得了结果。C=N异构化直接且有效地响应检测到的金属阳离子和其他活性物种（半胱氨酸、组氨酸、次氯酸根等），导致显著的荧光增强。本综述揭示了C=N键异构化/调制作为一种取决于荧光变化和构象限制的信号机制的过程。此外，尽管已经报道了几种基于这种信号机制的荧光传感器，但基于C=N键异构化的荧光传感器尚未得到很好的综述。因此，本综述对基于C=N的荧光传感器进行了总结。
