Department of Anesthesiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Eur Rev Med Pharmacol Sci. 2024 Mar;28(6):2493-2500. doi: 10.26355/eurrev_202403_35756.
The present study aimed to compare the effect of topical laryngeal lidocaine with intravenous lidocaine before endotracheal intubation on the incidence and severity of postoperative sore throat, hoarseness, and cough.
This prospective randomized controlled study enrolled 144 patients undergoing laparoscopic cholecystectomy with endotracheal intubation. The patients were randomized to three groups and received 2% lidocaine by topical laryngeal spray (group T), intravenous 2% lidocaine (group I), and the equivalent volume of intravenous saline (group C) before intubation. The incidence and severity of sore throat, hoarseness, and cough reaction at 0.5, 1, 6, and 24 h after extubation were collected.
The incidence of sore throat was significantly lower in group T than in groups I and C (6.4% vs. 37.2% and 86.7%, p < 0.001), respectively at 0.5 h after extubation, and it was significantly lower in group I than that in group C (37.2% vs. 86.7%, p < 0.001). Both the incidence of hoarseness and cough were significantly lower in group T than in group I and in group C (14.9% vs. 97.7% and 97.8%, p < 0.001, and 19.1% vs. 72.0% and 93.3%, p < 0.001), respectively. The severity of sore throat, hoarseness and cough in group T was significantly lower than that in group I and that in group C (p < 0.05), and it was significantly lower in group I than in group C (p < 0.05).
Both topical laryngeal lidocaine and intravenous lidocaine before intubation have positive effects on preventing sore throat. Topical laryngeal route was superior to intravenous route. Chictr.org.cn ID: ChiCTR2100042442.
本研究旨在比较气管插管前局部应用喉利多卡因与静脉应用利多卡因对术后咽痛、声音嘶哑和咳嗽发生率和严重程度的影响。
这是一项前瞻性随机对照研究，纳入了 144 例行气管插管腹腔镜胆囊切除术的患者。患者随机分为三组，在插管前分别接受 2%利多卡因喉喷雾剂（T 组）、静脉内 2%利多卡因（I 组）和静脉内等容量生理盐水（C 组）。记录拔管后 0.5、1、6 和 24 h 时咽痛、声音嘶哑和咳嗽反应的发生率和严重程度。
与 I 组和 C 组相比，T 组拔管后 0.5 h 时咽痛的发生率显著降低（6.4%比 37.2%和 86.7%，p<0.001），且 I 组显著低于 C 组（37.2%比 86.7%，p<0.001）。T 组的声音嘶哑和咳嗽发生率也显著低于 I 组和 C 组（14.9%比 97.7%和 97.8%，p<0.001，19.1%比 72.0%和 93.3%，p<0.001）。T 组咽痛、声音嘶哑和咳嗽的严重程度均显著低于 I 组和 C 组（p<0.05），且显著低于 I 组（p<0.05）。
气管插管前局部应用和静脉应用利多卡因均可有效预防咽痛，局部应用优于静脉应用。ChiCTR2100042442.
