Sumathi P A, Shenoy T, Ambareesha M, Krishna H M
Department of Anaesthesiology, Kasturba Medical College, Manipal 576104, India.
Br J Anaesth. 2008 Feb;100(2):215-8. doi: 10.1093/bja/aem341. Epub 2007 Nov 16.
Postoperative sore throat, cough, and hoarseness of voice though minor sequelae after general tracheal anaesthesia can be distressing to the patient.
This prospective, randomized, double blind, controlled study compares the incidence of postoperative sore throat, cough, and hoarseness of voice after general tracheal anaesthesia when applying betamethasone gel (betamethasone group) or lidocaine jelly (lidocaine group) on the tracheal tube. One hundred and fifty ASA class I and II patients undergoing elective surgeries under general orotracheal anaesthesia were randomized into three groups: betamethasone gel, lidocaine jelly, and control groups. In the post-anaesthesia care unit, a blinded anaesthesiologist interviewed all patients on postoperative sore throat, cough, and hoarseness of voice at 1, 6, 12, and 24 h after operation.
In the first 24 h after surgery, the incidence of postoperative sore throat was 40, 100, and 100%; cough was 6, 40, and 28%; and hoarseness of voice was 4.1, 32.9, and 50%, for the betamethasone, lidocaine and control groups, respectively. The incidence of postoperative sore throat, cough, and hoarseness of voice was significantly lower in the betamethasone group compared with the other two groups (P<0.05).
A wide spread application of betamethasone gel on the tracheal tube decreases the incidence and severity of postoperative sore throat, cough, and hoarseness of voice.
术后咽痛、咳嗽和声音嘶哑虽是全身气管麻醉后的轻微后遗症，但会令患者感到痛苦。
这项前瞻性、随机、双盲、对照研究比较了在气管导管上涂抹倍他米松凝胶（倍他米松组）或利多卡因凝胶（利多卡因组）后全身气管麻醉患者术后咽痛、咳嗽和声音嘶哑的发生率。150例接受择期口气管全身麻醉手术的ASA I级和II级患者被随机分为三组：倍他米松凝胶组、利多卡因凝胶组和对照组。在麻醉后护理单元，一名盲法麻醉医生在术后1、6、12和24小时对所有患者进行术后咽痛、咳嗽和声音嘶哑的访谈。
术后24小时内，倍他米松组、利多卡因组和对照组的术后咽痛发生率分别为40%、100%和100%；咳嗽发生率分别为6%、40%和28%；声音嘶哑发生率分别为4.1%、32.9%和50%。与其他两组相比，倍他米松组术后咽痛、咳嗽和声音嘶哑的发生率显著降低（P<0.05）。
在气管导管上广泛涂抹倍他米松凝胶可降低术后咽痛、咳嗽和声音嘶哑的发生率及严重程度。
