Suppr超能文献

影响范围：解析原生动物寄生虫中的嘌呤营养缺陷型

mSphere of Influence: Deciphering purine auxotrophy in protozoan parasites.

作者信息

Martorelli Di Genova Bruno

机构信息

Department of Microbiology and Molecular Genetics, Larner College of Medicine, University of Vermont, Burlington, Vermont, USA.

出版信息

mSphere. 2024 Apr 23;9(4):e0000724. doi: 10.1128/msphere.00007-24. Epub 2024 Apr 3.

DOI:10.1128/msphere.00007-24
PMID:38567972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11036795/
Abstract

Bruno Martorelli Di Genova works in parasitology, focusing on metabolism. In this mSphere of Influence article, he reflects on how the articles "Metabolic Reprogramming during Purine Stress in the Protozoan Pathogen " and "Yeast-Based High-Throughput Screen Identifies Equilibrative Nucleoside Transporter 1 Inhibitors That Kill Malaria Parasites" impacted him, informing his research strategies and understanding of metabolic flexibility in .

摘要

布鲁诺·马尔托雷利·迪·热那亚从事寄生虫学研究，专注于新陈代谢。在这篇“影响范围”文章中，他反思了《原生动物病原体嘌呤应激期间的代谢重编程》和《基于酵母的高通量筛选鉴定出杀死疟原虫的平衡核苷转运体1抑制剂》这两篇文章对他的影响，这些影响为他的研究策略提供了信息，并加深了他对[具体研究对象]代谢灵活性的理解。

相似文献

1
mSphere of Influence: Deciphering purine auxotrophy in protozoan parasites.影响范围：解析原生动物寄生虫中的嘌呤营养缺陷型
mSphere. 2024 Apr 23;9(4):e0000724. doi: 10.1128/msphere.00007-24. Epub 2024 Apr 3.
2
Targeting the Plasmodium vivax equilibrative nucleoside transporter 1 (PvENT1) for antimalarial drug development.以间日疟原虫平衡核苷转运蛋白1（PvENT1）为靶点进行抗疟药物研发。
Int J Parasitol Drugs Drug Resist. 2015 Nov 28;6(1):1-11. doi: 10.1016/j.ijpddr.2015.11.003. eCollection 2016 Apr.
3
Yeast-based high-throughput screen identifies Plasmodium falciparum equilibrative nucleoside transporter 1 inhibitors that kill malaria parasites.基于酵母的高通量筛选鉴定出可杀死疟原虫的恶性疟原虫平衡核苷转运体1抑制剂。
ACS Chem Biol. 2015 Mar 20;10(3):775-83. doi: 10.1021/cb500981y. Epub 2015 Jan 30.
4
Identification via a Parallel Hit Progression Strategy of Improved Small Molecule Inhibitors of the Malaria Purine Uptake Transporter that Inhibit Parasite Proliferation.通过平行命中进展策略鉴定出可抑制疟原虫嘌呤摄取转运蛋白并抑制寄生虫增殖的改良小分子抑制剂。
ACS Infect Dis. 2019 Oct 11;5(10):1738-1753. doi: 10.1021/acsinfecdis.9b00168. Epub 2019 Aug 14.
5
Purine import into malaria parasites as a target for antimalarial drug development.疟原虫的嘌呤摄取作为抗疟药物开发的靶点
Ann N Y Acad Sci. 2015 Apr;1342(1):19-28. doi: 10.1111/nyas.12568. Epub 2014 Nov 25.
6
Molecules targeting the purine salvage pathway in Apicomplexan parasites.针对顶复门寄生虫中嘌呤补救途径的分子。
Trends Parasitol. 2007 Aug;23(8):384-9. doi: 10.1016/j.pt.2007.06.003. Epub 2007 Jun 18.
7
Transport of purines and purine salvage pathway inhibitors by the Plasmodium falciparum equilibrative nucleoside transporter PfENT1.恶性疟原虫平衡核苷转运蛋白PfENT1对嘌呤和嘌呤补救途径抑制剂的转运
Mol Biochem Parasitol. 2010 Jan;169(1):40-9. doi: 10.1016/j.molbiopara.2009.10.001. Epub 2009 Oct 8.
8
Antiparasitic chemotherapy: tinkering with the purine salvage pathway.抗寄生虫化疗：对嘌呤补救途径的微调。
Adv Exp Med Biol. 2008;625:116-32. doi: 10.1007/978-0-387-77570-8_10.
9
Characterization of Plasmodium Atg3-Atg8 Interaction Inhibitors Identifies Novel Alternative Mechanisms of Action in Toxoplasma gondii.鉴定疟原虫 Atg3-Atg8 相互作用抑制剂的特性，确定刚地弓形虫中的新型作用机制。
Antimicrob Agents Chemother. 2018 Jan 25;62(2). doi: 10.1128/AAC.01489-17. Print 2018 Feb.
10
Uptake of purines in Plasmodium falciparum-infected human erythrocytes is mostly mediated by the human equilibrative nucleoside transporter and the human facilitative nucleobase transporter.恶性疟原虫感染的人类红细胞对嘌呤的摄取主要是由人嘧啶核苷转运蛋白和人嘌呤核苷转运蛋白介导的。
Malar J. 2010 Jan 29;9:36. doi: 10.1186/1475-2875-9-36.

本文引用的文献

1
From purines to purinergic signalling: molecular functions and human diseases.从嘌呤到嘌呤能信号转导：分子功能与人类疾病。
Signal Transduct Target Ther. 2021 Apr 28;6(1):162. doi: 10.1038/s41392-021-00553-z.
2
Purine auxotrophy: Possible applications beyond genetic marker.嘌呤营养缺陷型：超越遗传标记的可能应用。
Yeast. 2019 Nov;36(11):649-656. doi: 10.1002/yea.3434. Epub 2019 Aug 13.
3
Yeast-based high-throughput screen identifies Plasmodium falciparum equilibrative nucleoside transporter 1 inhibitors that kill malaria parasites.基于酵母的高通量筛选鉴定出可杀死疟原虫的恶性疟原虫平衡核苷转运体1抑制剂。
ACS Chem Biol. 2015 Mar 20;10(3):775-83. doi: 10.1021/cb500981y. Epub 2015 Jan 30.
4
Metabolic reprogramming during purine stress in the protozoan pathogen Leishmania donovani.原虫病原体利什曼原虫在嘌呤胁迫下的代谢重编程。
PLoS Pathog. 2014 Feb 27;10(2):e1003938. doi: 10.1371/journal.ppat.1003938. eCollection 2014 Feb.
5
GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis.G 蛋白偶联受体调节嘌呤生物合成的多酶复合物的组装。
Nat Chem Biol. 2011 Oct 23;7(12):909-15. doi: 10.1038/nchembio.690.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验