Iranian National Registry Center for Lophomoniasis and Toxoplasmosis Research Center, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
Toxicology and Forensic Medicine Division, Mazandaran Registry Center for Opioids Poisoning, Antimicrobial Resistance Research Centers, Imam Khomeini Hospital, Mazandaran University of Medical Sciences, Sari, Iran.
Foodborne Pathog Dis. 2024 Jun;21(6):360-365. doi: 10.1089/fpd.2023.0087. Epub 2024 Apr 3.
is a ubiquitous parasitic protozoan that may be an important cause of neurological and psychiatric diseases. The purpose of this case-control registry-based study was to evaluate the prevalence of infection and related risk factors among subjects who attempted suicide by drug use and a control group at the Iranian National Registry Center for Toxoplasmosis in Mazandaran Province, northern Iran. Baseline data were collected from participants using a questionnaire, and a blood sample was taken from each individual. The plasma was prepared for serological analysis, whereas the buffy coat was used for molecular analysis. Out of 282 individuals (147 cases with suicide attempters [SA] and 135 controls), 42.9% of patients and 16.3% of control subjects were positive for anti- immunoglobin G (IgG), but all participants were negative for DNA and anti- immunoglobin M. Based on multiple logistic regressions, IgG seropositivity in SA in the age group of 20-30 years was 3.22 times higher than that in the control group ( < 0.001). These findings suggest that latent infection among SA is significantly higher than that in healthy individuals, indicating a potential association between latent toxoplasmosis and SA at least in the studied area. Further research is needed to shed light on the potential association between and suicide among different populations and areas of the world.
是一种普遍存在的寄生原生动物，可能是神经和精神疾病的重要病因。本病例对照登记研究旨在评估在伊朗北部马赞达兰省的伊朗国家弓形体病登记中心，试图通过药物自杀的受试者和对照组中 感染的流行率及相关危险因素。使用问卷收集参与者的基线数据，并从每个人身上采集血样。血浆用于血清学分析，而白细胞层用于分子分析。在 282 名个体（147 名自杀未遂者[SA]和 135 名对照组）中，42.9%的患者和 16.3%的对照组对 免疫球蛋白 G（IgG）呈阳性反应，但所有参与者对 DNA 和抗免疫球蛋白 M 均呈阴性。基于多因素逻辑回归分析，20-30 岁年龄组 SA 患者 IgG 阳性率比对照组高 3.22 倍（<0.001）。这些发现表明，SA 中的潜伏 感染明显高于健康个体，这表明潜伏性弓形体病与 SA 之间至少在研究区域存在潜在关联。需要进一步研究来阐明不同人群和地区的 与自杀之间的潜在关联。
