Hinton R J, Dechow P C, Carlson D S
Oral Surg Oral Med Oral Pathol. 1985 Mar;59(3):247-51. doi: 10.1016/0030-4220(85)90160-4.
Intramuscular injection of 2% lidocaine hydrochloride with epinephrine (1:100,000) bilaterally into the masseter muscles of growing rats resulted in a 30% to 40% decrease in maximal stimulated bite force at 3 days following injection. By 6 days postinjection, bite force had begun to increase, but significant differences from control bite force levels were still present 15 days postinjection. By 25 days postinjection, recovery to control values was complete. These data are consistent with previously documented fiber destruction and subsequent regeneration following exposure to this and other local anesthetic agents. It is suggested that local myotoxic effects produced by the administration of such drugs may result in a transient functional deficit in the injected muscle(s) that may persist for up to 2 weeks.
对生长中的大鼠双侧咬肌进行肌内注射2%盐酸利多卡因加肾上腺素（1:100,000），在注射后3天，最大刺激咬合力降低了30%至40%。注射后6天，咬合力开始增加，但在注射后15天，与对照咬合力水平仍存在显著差异。注射后25天，恢复至对照值。这些数据与先前记录的暴露于这种及其他局部麻醉剂后纤维破坏及随后的再生情况一致。提示此类药物给药产生的局部肌毒性作用可能导致注射肌肉出现短暂的功能缺陷，且该缺陷可能持续长达2周。
