The Fourth Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Rehabiliation Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Cancer Immunol Res. 2024 Jun 4;12(6):652-662. doi: 10.1158/2326-6066.CIR-23-0976.
Myeloid-derived suppressor cells (MDSC) are a population of heterogeneous immune cells that are involved in precancerous conditions and neoplasms. The autonomic nervous system (ANS), which is composed of the sympathetic nervous system and the parasympathetic nervous system, is an important component of the tumor microenvironment that responds to changes in the internal and external environment mainly through adrenergic and cholinergic signaling. An abnormal increase of autonomic nerve density has been associated with cancer progression. As we discuss in this review, growing evidence indicates that sympathetic and parasympathetic signals directly affect the expansion, mobilization, and redistribution of MDSCs. Dysregulated autonomic signaling recruits MDSCs to form an immunosuppressive microenvironment in chronically inflamed tissues, resulting in abnormal proliferation and differentiation of adult stem cells. The two components of the ANS may also be responsible for the seemingly contradictory behaviors of MDSCs. Elucidating the underlying mechanisms has the potential to provide more insights into the complex roles of MDSCs in tumor development and lay the foundation for the development of novel MDSC-targeted anticancer strategies.
髓系来源的抑制性细胞（MDSC）是一群异质性的免疫细胞，参与癌前状态和肿瘤的发生。自主神经系统（ANS）由交感神经系统和副交感神经系统组成，是肿瘤微环境的重要组成部分，主要通过肾上腺素能和胆碱能信号对外界和内部环境的变化作出反应。自主神经密度的异常增加与癌症的进展有关。正如我们在这篇综述中所讨论的，越来越多的证据表明，交感和副交感信号直接影响 MDSC 的扩增、动员和再分布。失调的自主信号募集 MDSC 形成慢性炎症组织中的免疫抑制微环境，导致成体干细胞的异常增殖和分化。ANS 的两个组成部分也可能是 MDSC 看似矛盾行为的原因。阐明潜在的机制有可能深入了解 MDSC 在肿瘤发展中的复杂作用，并为开发针对 MDSC 的新型抗癌策略奠定基础。
