Shaanxi Key Laboratory of Brain Disorders, Institute of Basic Medical Sciences, Xi'an Medical University, Xi'an, China.
Key Lab for Thin Film and Microfabrication Technology, Department of Instrument Science and Engineering, School of Electronic Information and Electronic Engineering, Institute of Nano Biomedicine and Engineering, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
Front Immunol. 2020 Apr 24;11:737. doi: 10.3389/fimmu.2020.00737. eCollection 2020.
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid progenitor and precursor cells at different stages of differentiation, which play an important role in tumor immunosuppression. Glioma is the most common and deadliest primary malignant tumor of the brain, and ample evidence supports key contributions of MDSCs to the immunosuppressive tumor microenvironment, which is a key factor stimulating glioma progression. In this review, we summarize the source and characterization of MDSCs, discuss their immunosuppressive functions, and current approaches that target MDSCs for tumor control. Overall, the review provides insights into the roles of MDSC immunosuppression in the glioma microenvironment and suggests that MDSC control is a powerful cellular therapeutic target for currently incurable glioma tumors.
髓源性抑制细胞（MDSCs）是一组异质性的骨髓祖细胞和前体细胞，处于不同的分化阶段，在肿瘤免疫抑制中发挥重要作用。神经胶质瘤是最常见和最致命的原发性脑恶性肿瘤，大量证据支持 MDSC 对免疫抑制性肿瘤微环境的关键贡献，这是刺激神经胶质瘤进展的关键因素。在这篇综述中，我们总结了 MDSC 的来源和特征，讨论了它们的免疫抑制功能，以及目前针对 MDSC 进行肿瘤控制的方法。总的来说，该综述深入了解了 MDSC 免疫抑制在神经胶质瘤微环境中的作用，并表明 MDSC 控制是目前无法治愈的神经胶质瘤肿瘤的一种强大的细胞治疗靶标。
