16(S)-氨基前列地尔F2α甲酯的合成及其生物学特性
Synthesis and biological properties of 16(S)-amino-PGF2 alpha methyl ester.
作者信息
Ambrus G, Cseh G, Tóth-Sarudy E
出版信息
Prostaglandins. 1985 Feb;29(2):303-12. doi: 10.1016/0090-6980(85)90210-2.
PMID:3856905
Abstract
A synthesis of 16-amino-derivatives of PGF2 alpha is reported. Introduction of an amino group into position 16 of PGF2 alpha has decreased the sensitivity of the compound to metabolic degradation. 16(S)-amino-PGF2 alpha methyl ester shows high abortifacient activity with reduced diarrhoeic side effect.
摘要
据报道合成了前列腺素F2α的16-氨基衍生物。在前列腺素F2α的16位引入氨基降低了该化合物对代谢降解的敏感性。16(S)-氨基前列腺素F2α甲酯显示出高堕胎活性且腹泻副作用降低。
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