前列腺素E2降低大鼠睾丸睾酮水平
Reduction of testicular testosterone levels in rats by prostaglandin E2.
作者信息
Yamada K, Ohkura N, Satoh T
出版信息
Res Commun Chem Pathol Pharmacol. 1985 Jan;47(1):153-6.
PMID:3856906
Abstract
The effect of intratesticular administration of prostaglandin (PG) E2, PGF2 alpha and PGD2 on rat testes testosterone levels were studied. The intratesticular administration of PGE2 or PGD2 markedly decreased the testicular testosterone levels in rats. The decrease of testosterone concentration in rat testis was not obtained by PGF2 alpha. In the incubation experiment, PGE2 reduced the release of testosterone from fragment rat testis. These results suggest that PGE2 acts on androgen biosynthesis in rat testes.
摘要
研究了睾丸内注射前列腺素（PG）E2、PGF2α和PGD2对大鼠睾丸睾酮水平的影响。睾丸内注射PGE2或PGD2可显著降低大鼠睾丸中的睾酮水平。PGF2α未使大鼠睾丸中的睾酮浓度降低。在孵育实验中，PGE2减少了大鼠睾丸组织块中睾酮的释放。这些结果表明，PGE2作用于大鼠睾丸中的雄激素生物合成。
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