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中国北京市某区不同助产机构严重产后出血的特征及治疗:基于机构的回顾性队列研究。

Characteristics and treatment for severe postpartum haemorrhage in different midwifery hospitals in one district of Beijing in China: an institution-based, retrospective cohort study.

机构信息

Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.

National Clinical Research Centre for Obstetrics and Gynecology, Beijing, China.

出版信息

BMJ Open. 2024 Apr 3;14(4):e077709. doi: 10.1136/bmjopen-2023-077709.

Abstract

OBJECTIVE

To identify the characteristics and treatment approaches for patients with severe postpartum haemorrhage (SPPH) in various midwifery institutions in one district in Beijing, especially those without identifiable antenatal PPH high-risk factors, to improve regional SPPH rescue capacity.

DESIGN

Retrospective cohort study.

SETTING

This study was conducted at 9 tertiary-level hospitals and 10 secondary-level hospitals in Haidian district of Beijing from January 2019 to December 2022.

PARTICIPANTS

The major inclusion criterion was SPPH with blood loss ≥1500 mL or needing a packed blood product transfusion ≥1000 mL within 24 hours after birth. A total of 324 mothers with SPPH were reported to the Regional Obstetric Quality Control Office from 19 midwifery hospitals.

OUTCOME MEASURES

The pregnancy characteristics collected included age at delivery, gestational weeks at delivery, height, parity, delivery mode, antenatal PPH high-risk factors, aetiology of PPH, bleeding amount, PPH complications, transfusion volume and PPH management. SPPH characteristics were compared between two levels of midwifery hospitals and their association with antenatal PPH high-risk factors was determined.

RESULTS

SPPH was observed in 324 mothers out of 106 697 mothers in the 4 years. There were 74.4% and 23.9% cases of SPPH without detectable antenatal PPH high-risk factors in secondary and tertiary midwifery hospitals, respectively. Primary uterine atony was the leading cause of SPPH in secondary midwifery hospitals, whereas placental-associated disorders were the leading causes in tertiary institutions. Rates of red blood cell transfusion over 10 units, unscheduled returns to the operating room and adverse PPH complications were higher in patients without antenatal PPH high-risk factors. Secondary hospitals had significantly higher rates of trauma compared with tertiary institutions.

CONCLUSION

Examining SPPH cases at various institutional levels offers a more comprehensive view of regional SPPH management and enhances targeted training in this area.

摘要

目的

在北京海淀区的 9 所三级医院和 10 所二级医院中,识别各种助产机构中重度产后出血(PPH)患者的特征和治疗方法,特别是那些没有可识别的产前 PPH 高危因素的患者,以提高区域 PPH 抢救能力。

设计

回顾性队列研究。

地点

本研究于 2019 年 1 月至 2022 年 12 月在北京市海淀区的 9 所三级医院和 10 所二级医院进行。

参与者

主要纳入标准为产后 24 小时内出血量≥1500ml 或需要输血≥1000ml 的 SPPH。共有 324 名 SPPH 产妇向区域产科质量控制办公室报告了 19 家助产医院。

结局测量

收集的妊娠特征包括分娩时的年龄、分娩时的孕周、身高、产次、分娩方式、产前 PPH 高危因素、PPH 的病因、出血量、PPH 并发症、输血量和 PPH 管理。比较了两级助产医院的 SPPH 特征,并确定了它们与产前 PPH 高危因素的关系。

结果

在 4 年期间,在 106697 名产妇中观察到 324 名 SPPH 产妇。二级和三级助产医院中,无产前 PPH 高危因素的 SPPH 分别占 74.4%和 23.9%。原发性子宫收缩乏力是二级助产医院 SPPH 的主要原因,而胎盘相关疾病是三级医院的主要原因。无产前 PPH 高危因素的患者红细胞输注量超过 10 单位、非计划返回手术室和不良 PPH 并发症的发生率更高。与三级医院相比,二级医院的创伤发生率明显更高。

结论

检查不同机构水平的 SPPH 病例可以更全面地了解区域内 PPH 的管理情况,并加强该领域的针对性培训。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e554/11146356/b5a49dc8bedb/bmjopen-2023-077709f01.jpg

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