Department of Restorative Dentistry, Royal London Hospital, BartsHealth NHS Trust, London, UK.
Institute of Dentistry Queen Mary University of London, London, UK.
Haemophilia. 2024 Apr;30 Suppl 3:128-134. doi: 10.1111/hae.15005. Epub 2024 Apr 3.
Advances in haematological therapies for people with complex or rare inherited bleeding disorders (IBD) have resulted in them living longer, retaining their natural teeth with greater expectations of function and aesthetics. Dental management strategies need to evolve to meet these challenges. Utilising low level laser diode therapy to reduce pre-operative inflammation to reduce the intraoperative and postoperative burden on haemostasis is described in a case series of 12 patients. For these individuals who previously required further medical management to support haemostasis or experienced such prolonged haemorrhage sufficient to warrant hospital admission, haemostasis was achieved in the dental surgery such that they were able to return home with no further medical intervention or overnight stays. Global inequities in accessing novel treatments for complex or rare IBD necessitates a comprehensive understanding of the local haemostatic agents available to dentists and the most commonly used agents and techniques are described including the use of single tooth anaesthesia (STA). STA is a computerised delivery mechanism that allows routine dental procedures that would previously have required block injections needing factor replacement therapy to be undertaken safely and effectively with no additional haemostatic intervention. The challenges of inhibitors in oral surgery are explained and discussed although more research and evidence is required to establish new treatment protocols. The importance of establishing good dental health in the quality of life of people with complex or rare IBD is highlighted with respect to the dental specific impact that more novel therapies may have on people with IBD.
血液学疗法在治疗复杂或罕见遗传性出血性疾病(IBD)方面的进展,使患者的寿命延长,保留了天然牙齿,对功能和美观的期望也更高。因此,牙科管理策略需要不断发展以应对这些挑战。利用低水平激光二极管疗法减少术前炎症,以减轻术中及术后的止血负担,这在 12 例患者的病例系列中得到了描述。对于这些以前需要进一步的医疗管理来支持止血,或经历过如此长时间的出血,以至于需要住院治疗的患者,在牙科手术中实现了止血,使他们能够在没有进一步的医疗干预或过夜的情况下回家。由于全球在获得复杂或罕见 IBD 的新型治疗方法方面存在不平等现象,因此需要全面了解牙医可用的局部止血剂,并且描述了最常用的止血剂和技术,包括单牙麻醉(STA)的使用。STA 是一种计算机化的输送机制,允许以前需要因子替代治疗的常规牙科手术安全有效地进行,而无需额外的止血干预。虽然需要更多的研究和证据来建立新的治疗方案,但解释和讨论了口腔外科中抑制剂的挑战。强调了在复杂或罕见 IBD 患者的生活质量方面建立良好的口腔健康的重要性,因为更新型的治疗方法可能会对 IBD 患者产生特定的口腔影响。