Kunjan Faris, Shanmugam Rajeshkumar, Govindharaj Sulochana
Nanobiomedicine Lab, Centre for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, IND.
Cureus. 2024 Mar 4;16(3):e55472. doi: 10.7759/cureus.55472. eCollection 2024 Mar.
Background In this research, iron oxide nanoparticles were synthesized using stem extract, which is used for various diseases such as throat infection, cough, fever, nasal congestion, and digestive problems. Aim This study aimed to formulate a green synthesis of iron oxide nanoparticles mediated by (known as karpuravalli in Tamil) and assess its antimicrobial and antioxidant properties. Materials and methods Iron oxide nanoparticles were synthesized, and then their antimicrobial properties were tested against two specific pathogens, i.e., and using the agar well diffusion technique. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, hydroxyl radical scavenging (HO) assay, and ferric ion reducing antioxidant power (FRAP) assay were conducted to check the free radical scavenging activity. Result The results obtained showed that these iron oxide nanoparticles showed better antimicrobial activity against when compared to and the antioxidant activity showed a very close efficacy when compared to the standard. Conclusion The research has demonstrated the high antioxidant activity and high antibacterial activity of iron oxide nanoparticles using stem anatural and cheaper antimicrobial drug compared to the drugs present on the market.
背景 在本研究中，使用茎提取物合成了氧化铁纳米颗粒，该提取物用于治疗多种疾病，如咽喉感染、咳嗽、发烧、鼻塞和消化问题。 目的 本研究旨在通过（泰米尔语中称为卡尔普拉瓦利）介导的氧化铁纳米颗粒的绿色合成，并评估其抗菌和抗氧化性能。 材料和方法 合成了氧化铁纳米颗粒，然后使用琼脂孔扩散技术针对两种特定病原体，即 和 测试其抗菌性能。进行了2,2-二苯基-1-苦基肼（DPPH）测定、羟基自由基清除（HO）测定和铁离子还原抗氧化能力（FRAP）测定，以检查自由基清除活性。 结果 获得的结果表明，与 相比，这些氧化铁纳米颗粒对 显示出更好的抗菌活性，并且与标准品相比，抗氧化活性显示出非常接近的功效。 结论 该研究证明了使用 茎合成的氧化铁纳米颗粒具有高抗氧化活性和高抗菌活性，与市场上现有的药物相比，它是一种天然且更便宜的抗菌药物。
