Moran J, Addy M
J Oral Rehabil. 1985 Jan;12(1):81-90. doi: 10.1111/j.1365-2842.1985.tb00623.x.
Few studies have reported the maximum potential of surfaces to adsorb the cationic antiseptics and few comparisons between antiseptics have been carried out. The purpose of this investigation was to measure the maximum uptake of alexidine, cetyl pyridinium chloride, chlorhexidine gluconate and chlorhexidine acetate to polymethylmethacrylate and by the construction of adsorption isotherms determine the pattern of molecular attachment to the recipient surface. The mean maximum adsorption findings for these antiseptics demonstrated significantly greater uptake of cetyl pyridinium chloride than the other antiseptics and significantly less uptake of alexidine compared with the other antiseptics. All four antiseptics showed a Langmuir type adsorption isotherm consistent with the formation of a monolayer of molecules on the recipient surface. For chlorhexidine preliminary studies demonstrated that the pattern of adsorption was not altered by saliva pre-treatment of surfaces. No evidence of molecular multilayering was observed even at higher concentrations of the antiseptics. However, the maximum uptake on to the surface was significantly increased when no post-treatment washings were carried out. It was concluded that this increased uptake would be unlikely to play an important role in antiplaque activity because of its relative instability. The pH dependency for the adsorption of these antiseptics was demonstrated such that as previously observed for chlorhexidine gluconate at low pH adsorption is almost completely, or completely, prevented.
很少有研究报道表面吸附阳离子防腐剂的最大潜力，并且很少对防腐剂进行比较。本研究的目的是测量聚甲基丙烯酸甲酯对阿利西定、十六烷基氯化吡啶、葡萄糖酸氯己定和醋酸氯己定的最大吸收量，并通过构建吸附等温线来确定分子与接受表面的附着模式。这些防腐剂的平均最大吸附结果表明，十六烷基氯化吡啶的吸收量明显高于其他防腐剂，而阿利西定的吸收量明显低于其他防腐剂。所有四种防腐剂均呈现朗缪尔型吸附等温线，这与在接受表面形成单分子层一致。对于氯己定，初步研究表明，表面经唾液预处理后，吸附模式未发生改变。即使在较高浓度的防腐剂下，也未观察到分子多层现象。然而，当不进行后处理冲洗时，表面的最大吸收量显著增加。得出的结论是，由于其相对不稳定性，这种增加的吸收量不太可能在抗牙菌斑活性中发挥重要作用。已证明这些防腐剂吸附的pH依赖性，如先前观察到的葡萄糖酸氯己定在低pH下几乎完全或完全阻止吸附。
