Addy M, Roberts W R
J Periodontol. 1981 Jul;52(7):380-5. doi: 10.1902/jop.1981.52.7.380.
This study assessed the value of acrylic, in powder and optically clear forms, to measure the adsorption and staining properties of some cationic antiseptics. The uptake of chlorhexidine gluconate, chlorhexidine acetate, alexidine and cetyl pyridinium chloride onto acrylic powder was measured spectrophotometrically. Similarly, tea staining of perspex blocks exposed twice daily to the antiseptics and hexetidine, was measured over a 5 day period. The adsorption of chlorhexidine gluconate and acetate was similar and greater than alexidine but less than cetyl pyridinium chloride. Desorption of the adsorbed antiseptics was minimal after 48 hours soaking in water. Acid produced a variable desorption of antiseptics. Tea staining of blocks was significantly greater with antiseptic treated specimens compared to control specimens. However, staining resulting from alexidine was greater than cetyl pyridinium chloride which was greater than chlorhexidine. Hexetidine produced the least staining. Saliva treatment of specimens only increased the tea staining of control blocks. The results indicated that adsorption levels alone would not explain the differences in antiplaque and staining activity reported for the cationic antiseptics.
本研究评估了粉末状和光学透明状的丙烯酸树脂在测量某些阳离子防腐剂的吸附和染色特性方面的价值。采用分光光度法测定葡萄糖酸氯己定、醋酸氯己定、阿利西定和十六烷基吡啶氯化物在丙烯酸树脂粉末上的摄取量。同样，对每天两次暴露于防腐剂和己脒定的有机玻璃块进行5天的茶渍染色测量。葡萄糖酸氯己定和醋酸氯己定的吸附情况相似，且大于阿利西定，但小于十六烷基吡啶氯化物。在水中浸泡48小时后，吸附的防腐剂的解吸作用极小。酸会使防腐剂产生不同程度的解吸。与对照标本相比，经防腐剂处理的标本的玻璃块茶渍染色明显更严重。然而，阿利西定导致的染色大于十六烷基吡啶氯化物，而十六烷基吡啶氯化物又大于氯己定。己脒定产生的染色最少。对标本进行唾液处理只会增加对照玻璃块的茶渍染色。结果表明，仅吸附水平无法解释所报道的阳离子防腐剂在抗牙菌斑和染色活性方面的差异。
