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2023年越南北方肺炎支原体23S rRNA基因的新型变异和已知突变

Novel Variant and Known Mutation in 23S rRNA Gene of Mycoplasma pneumoniae, Northern Vietnam, 2023.

作者信息

Nguyen Dinh-Dung, Ho Nhan Thi, Dover Lynn G, Vo Anh Hang Mai, Ly Ha Thi Thanh, Doan Phuong Mai, Nguyen Hang Thi, Luu Nguyen Thi Thao, Pham An Nhat, Tran Huyen Thi Thanh

出版信息

Emerg Infect Dis. 2024 May;30(5):1034-1036. doi: 10.3201/eid3005.231632. Epub 2024 Apr 4.

DOI:10.3201/eid3005.231632
PMID:38573165
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11060462/
Abstract

During a 2023 outbreak of Mycoplasma pneumoniae-associated community-acquired pneumonia among children in northern Vietnam, we analyzed M. pneumoniae isolated from nasopharyngeal samples. In almost half (6 of 13) of samples tested, we found known A2063G mutations (macrolide resistance) and a novel C2353T variant on the 23S rRNA gene.

摘要

在2023年越南北部儿童支原体肺炎相关社区获得性肺炎疫情期间，我们分析了从鼻咽样本中分离出的肺炎支原体。在几乎一半（13份样本中的6份）检测样本中，我们在23S rRNA基因上发现了已知的A2063G突变（大环内酯耐药）和一种新的C2353T变异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a61d/11060462/f9ad0b6c9f1f/23-1632-F.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a61d/11060462/f9ad0b6c9f1f/23-1632-F.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a61d/11060462/f9ad0b6c9f1f/23-1632-F.jpg

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本文引用的文献

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Nat Commun. 2021 Jun 9;12(1):3494. doi: 10.1038/s41467-021-23555-5.
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Macrolide-Resistant Mycoplasma pneumoniae Infections in Pediatric Community-Acquired Pneumonia.儿童社区获得性肺炎中耐大环内酯类肺炎支原体感染。
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Pneumonia in Children and Adolescents.儿童和青少年肺炎
应对疫情：2022 - 2023年武汉地区通过靶向新一代测序技术对儿童肺炎进行的综合分析
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The high-incidence period of Mycoplasma pneumoniae infections 2023/2024 in southeast Germany was associated with a low level of macrolide resistance.德国东南部2023/2024年肺炎支原体感染的高发期与大环内酯类耐药性水平较低有关。
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