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肺炎支原体 23S rRNA 基因突变频率在儿童和成人社区获得性肺炎中的差异：突变赋予大环内酯类耐药的临床影响。

Differences in the frequency of 23S rRNA gene mutations in Mycoplasma pneumoniae between children and adults with community-acquired pneumonia: clinical impact of mutations conferring macrolide resistance.

机构信息

Department of Laboratory Medicine, Inje University College of Medicine, Seoul, Republic of Korea.

出版信息

Antimicrob Agents Chemother. 2012 Dec;56(12):6393-6. doi: 10.1128/AAC.01421-12. Epub 2012 Sep 24.

DOI:10.1128/AAC.01421-12
PMID:23006753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3497172/
Abstract

We investigated the frequency and clinical significance of macrolide resistance in adult and pediatric patients with community-acquired pneumonia from a Mycoplasma pneumoniae infection. The frequency of the A2063G mutation in the 23S rRNA gene was significantly higher in children than in adults (61.3% [19/31] and 13.3% [8/60], respectively; P < 0.001). Patients with macrolide-resistant M. pneumoniae infections showed a longer duration of fever (P = 0.021) and required a longer duration of antibiotic treatment (P = 0.007).

摘要

我们研究了肺炎支原体感染所致成人和儿童社区获得性肺炎患者大环内酯类耐药的频率及其临床意义。23S rRNA 基因 A2063G 突变的频率在儿童中显著高于成人（61.3% [19/31] 和 13.3% [8/60]；P < 0.001）。大环内酯类耐药肺炎支原体感染患者发热持续时间更长（P = 0.021），抗生素治疗时间也更长（P = 0.007）。

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本文引用的文献

1
Macrolide-resistant Mycoplasma pneumoniae in adolescents with community-acquired pneumonia.青少年社区获得性肺炎中耐大环内酯类肺炎支原体。
BMC Infect Dis. 2012 May 31;12:126. doi: 10.1186/1471-2334-12-126.
2
Mycoplasma pneumoniae pneumonia in children.儿童支原体肺炎
Korean J Pediatr. 2012 Feb;55(2):42-7. doi: 10.3345/kjp.2012.55.2.42. Epub 2012 Feb 14.
3
Antibiotic sensitivity of 40 Mycoplasma pneumoniae isolates and molecular analysis of macrolide-resistant isolates from Beijing, China.中国北京 40 株肺炎支原体分离株的抗生素敏感性及大环内酯类耐药株的分子分析。
Antimicrob Agents Chemother. 2012 Feb;56(2):1108-9. doi: 10.1128/AAC.05627-11. Epub 2011 Nov 21.
4
Two unexpected phenomena in macrolide-resistant Mycoplasma pneumoniae infection in Japan and the unique biological characteristics of Mycoplasma pneumoniae.日本大环内酯类耐药肺炎支原体感染中的两种意外现象及肺炎支原体的独特生物学特性
J Infect Chemother. 2011 Oct;17(5):735-6. doi: 10.1007/s10156-011-0235-0. Epub 2011 Mar 25.
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Decline in erythromycin resistance in group A Streptococci from acute pharyngitis due to changes in the emm Genotypes rather than restriction of antibiotic use.A组链球菌对红霉素的耐药性下降是由于emm基因型的改变，而非抗生素使用受限，这一现象源于急性咽炎。
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Community-acquired macrolide-resistant Mycoplasma pneumoniae pneumonia in patients more than 18 years of age.18 岁以上患者获得性大环内酯类耐药肺炎支原体肺炎。
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High prevalence of macrolide resistance in Mycoplasma pneumoniae isolates from adult and adolescent patients with respiratory tract infection in China.中国成人和青少年呼吸道感染肺炎支原体分离株中大环内酯类耐药率高。
Clin Infect Dis. 2010 Jul 15;51(2):189-94. doi: 10.1086/653535.
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J Infect Chemother. 2010 Apr;16(2):78-86. doi: 10.1007/s10156-009-0021-4. Epub 2010 Jan 22.
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A comparative clinical study of macrolide-sensitive and macrolide-resistant Mycoplasma pneumoniae infections in pediatric patients.大环内酯类药物敏感与耐药肺炎支原体感染患儿的临床对比研究。
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