超重/肥胖儿童的睡眠行为与皮质下脑结构形态：一项横断面研究
Sleep Behaviors and the Shape of Subcortical Brain Structures in Children with Overweight/Obesity: A Cross-Sectional Study.
作者信息
Cadenas-Sanchez Cristina, Migueles Jairo H, Torres-Lopez Lucia V, Verdejo-Román Juan, Jiménez-Pavón David, Hillman Charles H, Catena Andrés, Ortega Francisco B
机构信息
Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain.
出版信息
Indian J Pediatr. 2024 Apr 4. doi: 10.1007/s12098-024-05094-1.
OBJECTIVES
To examine the relationship between sleep and subcortical brain structures using a shape analysis approach.
METHODS
A total of 98 children with overweight/obesity (10.0 ± 1.1 y, 59 boys) were included in the cross-sectional analyses. Sleep behaviors (i.e., wake time, sleep onset time, total time in bed, total sleep time, sleep efficiency, and wakening after sleep onset) were estimated with wrist-worn accelerometers. The shape of the subcortical brain structures was acquired by magnetic resonance imaging. A partial correlation permutation approach was used to examine the relationship between sleep behaviors and brain shapes.
RESULTS
Among all the sleep variables studied, only total time in bed was significantly related to pallidum and putamen structure, such that those children who spent more time in bed had greater expansions in the right and left pallidum (211-751 voxels, all p's <0.04) and right putamen (1783 voxels, p = 0.03).
CONCLUSIONS
These findings suggest that more time in bed was related to expansions on two subcortical brain regions in children with overweight/obesity.
目的
采用形状分析方法研究睡眠与大脑皮质下结构之间的关系。
方法
横断面分析纳入了98名超重/肥胖儿童（10.0±1.1岁，59名男孩）。使用腕部佩戴的加速度计估计睡眠行为（即清醒时间、入睡时间、卧床总时间、总睡眠时间、睡眠效率和入睡后觉醒情况）。通过磁共振成像获取大脑皮质下结构的形状。采用偏相关置换法研究睡眠行为与脑形状之间的关系。
结果
在所有研究的睡眠变量中，只有卧床总时间与苍白球和壳核结构显著相关，即卧床时间较长的儿童，其右侧和左侧苍白球（211 - 751体素，所有p值<0.04）和右侧壳核（1783体素，p = 0.03）有更大的扩展。
结论
这些发现表明，超重/肥胖儿童卧床时间越长，与两个大脑皮质下区域的扩展有关。
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