Sleep and Brain Plasticity Centre, Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London (KCL), UK; Department of Neurosurgery, King's College Hospital, London, UK.
Department of Neurosurgery, King's College Hospital, London, UK.
Sleep Med Rev. 2020 Aug;52:101317. doi: 10.1016/j.smrv.2020.101317. Epub 2020 Apr 22.
Early studies posited a relationship between sleep and the basal ganglia, but this relationship has received little attention recently. It is timely to revisit this relationship, given new insights into the functional anatomy of the basal ganglia and the physiology of sleep, which has been made possible by modern techniques such as chemogenetic and optogenetic mapping of neural circuits in rodents and intracranial recording, functional imaging, and a better understanding of human sleep disorders. We discuss the functional anatomy of the basal ganglia, and review evidence implicating their role in sleep. Whilst these studies are in their infancy, we suggest that the basal ganglia may play an integral role in the sleep-wake cycle, specifically by contributing to a thalamo-cortical-basal ganglia oscillatory network in slow-wave sleep which facilitates neural plasticity, and an active state during REM sleep which enables the enactment of cognitive and emotional networks. A better understanding of sleep mechanisms may pave the way for more effective neuromodulation strategies for sleep and basal ganglia disorders.
早期研究提出睡眠与基底神经节之间存在关系，但最近这一关系很少受到关注。鉴于现代技术（如啮齿动物神经回路的化学遗传学和光遗传学映射、颅内记录、功能成像以及对人类睡眠障碍的更好理解）使我们对基底神经节的功能解剖结构和睡眠生理学有了新的认识，重新审视这一关系恰逢其时。我们讨论了基底神经节的功能解剖结构，并回顾了表明其在睡眠中的作用的证据。虽然这些研究还处于起步阶段，但我们认为基底神经节可能在睡眠-觉醒周期中发挥重要作用，特别是通过在慢波睡眠中促进丘脑-皮质-基底神经节振荡网络来促进神经可塑性，以及在 REM 睡眠中保持活跃状态，从而实现认知和情感网络的表达。对睡眠机制的更好理解可能为睡眠和基底神经节障碍的更有效的神经调节策略铺平道路。
Zotero 插件