College of Marine Ecology and Environment, Shanghai Ocean University, Shanghai, 201306, China; National Marine Environmental Monitoring Center, Dalian, 116023, China.
National Marine Environmental Monitoring Center, Dalian, 116023, China; College of Marine Technology and Environment, Dalian Ocean University, Dalian, 116023, China.
Mar Environ Res. 2024 May;197:106470. doi: 10.1016/j.marenvres.2024.106470. Epub 2024 Mar 30.
In this study, the pollution status of antibiotics and ARGs in sediments from the land-sea intersection of Liaodong Bay was analyzed. The results showed that the level of antibiotic pollution ranged from ND to 433.27 ng/kg, with quinolones and tetracycline as the dominant antibiotics. The relative abundance of ARGs ranged from 3.62 × 10 to 1.32 × 10 copies/16SrRNA copies, with aminoglycoside and MLSB resistance genes being dominant. Regarding spatial distribution, the land and estuary areas showed higher antibiotic pollution levels than the offshore areas. Similarly, the land and estuary areas exhibited higher antibiotic diversity than the offshore areas. The ARGs were widely distributed on land, and their abundance gradually decreased to the downstream estuary area. Land and coastal areas exhibited higher ARG diversity than estuary areas. Analysis of environmental factors revealed a significant correlation between ARGs and non-corresponding antibiotics, and some ARGs were affected by heavy metals Cu and Pb.
本研究分析了辽东湾陆海交界区沉积物中抗生素和抗生素抗性基因（ARGs）的污染状况。结果表明，抗生素污染水平范围为未检出到 433.27ng/kg，以喹诺酮类和四环素类抗生素为主。ARGs 的相对丰度范围为 3.62×10-1.32×10 拷贝/16SrRNA 拷贝，以氨基糖苷类和 MLSB 类抗性基因为主。就空间分布而言，陆地和河口区的抗生素污染水平高于近海海域。同样，陆地和河口区的抗生素多样性也高于近海海域。ARGs 广泛分布于陆地，其丰度逐渐向下游河口区降低。陆地和沿海地区的 ARG 多样性高于河口地区。环境因子分析表明，ARGs 与相应抗生素之间存在显著相关性，一些 ARGs 受重金属 Cu 和 Pb 的影响。
