Research Center for Environment and Human Health, Research Center for Medicine and Social Development, School of Public Health, Chongqing Medical University, Chongqing 401331, PR China.
Duke Global Health Institute, Duke University, Durham, NC, United States.
J Hazard Mater. 2024 May 15;470:134160. doi: 10.1016/j.jhazmat.2024.134160. Epub 2024 Mar 31.
To investigate the effects of polycyclic aromatic hydrocarbons(PAHs) on puberty in boys.
695 subjects were selected from four primary schools in Chongqing, China. 675 urine samples from these boys were collected four PAH metabolites: 1-hydroxypyrene, 2-hydroxynaphthoic, 2-hydroxyfluorene, and 9-hydroxyphenanthrene. Pubertal development of 695 boys was assessed at follow-up visits starting in December 2015 and occurring every six months thereafter until now, data used in this article ending in June 2021. A total of 12 follow-up visits were performed. Cox proportional hazards regression models were used to analyze the relationship between PAH metabolite concentrations and indicators of pubertal timing.
The mean age at puberty onset of testicular volume, facial hair, pubic hair, first ejaculation, and axillary hair in boys was 11.66, 12.43, 12.51, 12.72 and 13.70 years, respectively. Cox proportional hazards regression models showed that boys with moderate level of 1-OHPyr exposure was associated with earlier testicular development (hazard ratio [HR] = 1.276, 95% confidence interval [CI]: 1.006-1.619), with moderate level of 2-OHNap were at higher risk of early testicular development (HR = 1.273, 95% CI: 1.002-1.617) and early axillary hair development (HR = 1.355, 95% CI: 1.040-1.764), with moderate level of 2-OHFlu was associated with earlier pubic hair development (HR = 1.256, 95% CI: 1.001-1.577), with high level of 9-OHPhe were at higher risk of early fisrt ejaculation (HR = 1.333, 95% CI: 1.005-1.767) and early facial hair development (HR = 1.393, 95% CI: 1.059-1.831).
Prepubertal exposure to PAHs may be associated with earlier pubertal development in boys.
探讨多环芳烃（PAHs）对男孩青春期的影响。
本研究从中国重庆市的四所小学中选取了 695 名研究对象。收集了这些男孩的 675 份尿液样本，检测了 4 种 PAH 代谢物：1-羟基芘、2-羟基萘酸、2-羟基芴和 9-羟基菲。从 2015 年 12 月开始，对 695 名男孩进行了随访，此后每 6 个月进行一次，直到 2021 年 6 月。共进行了 12 次随访。使用 Cox 比例风险回归模型分析了 PAH 代谢物浓度与青春期起始指标之间的关系。
男孩睾丸体积、阴毛、腋毛、首次遗精和胡须出现的平均年龄分别为 11.66 岁、12.43 岁、12.51 岁、12.72 岁和 13.70 岁。Cox 比例风险回归模型显示，中水平 1-OHPyr 暴露与睾丸发育较早有关（危险比[HR] = 1.276，95%置信区间[CI]：1.006-1.619），中水平 2-OHNap 暴露与睾丸发育较早（HR = 1.273，95%CI：1.002-1.617）和腋毛发育较早（HR = 1.355，95%CI：1.040-1.764）有关，中水平 2-OHFlu 与阴毛发育较早有关（HR = 1.256，95%CI：1.001-1.577），高水平 9-OHPhe 与首次遗精和胡须发育较早有关（HR = 1.333，95%CI：1.005-1.767）和面部毛发发育较早（HR = 1.393，95%CI：1.059-1.831）。
青春期前接触 PAHs 可能与男孩青春期提前有关。
