School of Public Health, Research Center for Medicine and Social Development, Chongqing Medical University, No. 61, University Town Middle Road, Shapingba District, Chongqing, 400016, China.
Int Arch Occup Environ Health. 2024 Oct;97(8):879-889. doi: 10.1007/s00420-024-02093-9. Epub 2024 Jul 29.
The aim of this study was to investigate the relationship between childhood polycyclic aromatic hydrocarbon (PAH) exposure and emotional and behavioral problems in adolescence.
Participants included 998 school-age children aged 7-12 years (514 girls and 484 boys). Metabolite concentrations of four PAHs (1-hydroxypyrene [1-OHPyr], 2-hydroxynaphthalene [2-OHNap], 2-hydroxyfluorine [2-OHFlu], and 9-hydroxyphenanthrene [9-OHPhe]) were measured in urine samples at baseline (Dec 2014-Dec 2015). During adolescence, we measured emotional and behavioral problems in study participants. We used logistic regression models to assess the effects of different levels of PAH metabolite concentrations on emotional and behavioral problems for boys and girls, separately.
Boys exposed to 1-OHPyr and 2-OHFlu had a significantly higher risk of externalizing problems (OR: 2.62, 95% CI: 1.09 ~ 6.29; OR: 2.92, 95% CI: 1.15 ~ 7.42). 2-OHNap exposure faced a higher risk of internalizing problems (OR: 3.85, 95% CI: 1.28 ~ 11.58; OR: 3.63, 95% CI: 1.13 ~ 11.63) and externalizing problems (OR: 4.27, 95% CI: 1.44 ~ 12.70; OR: 4.68, 95% CI: 1.49 ~ 14.73). Moreover, boys exposed to 9-OHPhe exhibited a significant risk of anxiety (OR: 2.84, 95% CI: 1.01 ~ 7.97; OR: 3.00, 95% CI: 1.04 ~ 8.68). Similarly, girls exposed to 9-OHPhe had a significant risk of anxiety (OR: 2.41, 95% CI: 1.25 ~ 4.64).
Childhood PAH exposures are associated with emotional and behavioral problems in adolescence, and boys seem more susceptible than girls.
本研究旨在探讨儿童多环芳烃（PAH）暴露与青春期情绪和行为问题之间的关系。
研究对象为 998 名 7-12 岁的学龄儿童（514 名女孩和 484 名男孩）。在基线（2014 年 12 月至 2015 年 12 月）时，检测尿液样本中四种 PAH 代谢物（1-羟基芘[1-OHPyr]、2-羟基萘[2-OHNap]、2-羟基芴[2-OHFlu]和 9-羟基菲[9-OHPhe]）的浓度。在青春期，我们对研究参与者的情绪和行为问题进行了测量。我们使用逻辑回归模型，分别评估了不同水平的 PAH 代谢物浓度对男孩和女孩情绪和行为问题的影响。
暴露于 1-OHPyr 和 2-OHFlu 的男孩发生外化问题的风险显著升高（OR：2.62，95%CI：1.096.29；OR：2.92，95%CI：1.157.42）。2-OHNap 暴露与内化问题（OR：3.85，95%CI：1.2811.58；OR：3.63，95%CI：1.1311.63）和外化问题（OR：4.27，95%CI：1.4412.70；OR：4.68，95%CI：1.4914.73）的风险升高相关。此外，暴露于 9-OHPhe 的男孩出现焦虑的风险显著升高（OR：2.84，95%CI：1.017.97；OR：3.00，95%CI：1.048.68）。同样，暴露于 9-OHPhe 的女孩出现焦虑的风险显著升高（OR：2.41，95%CI：1.25~4.64）。
儿童时期多环芳烃暴露与青春期的情绪和行为问题有关，男孩似乎比女孩更易受影响。
