Health Sciences University, Izmir Bozyaka Training and Research Hospital, Department of Internal Medicine, Karabaglar, Izmir, Turkey.
Izmir Kâtip Celebi University Faculty of Medicine, Department of Pharmacology and Toxicology, Izmir, Turkey.
Am J Med Sci. 2024 Jul;368(1):25-32. doi: 10.1016/j.amjms.2024.03.023. Epub 2024 Apr 3.
Stathmin is a phosphoprotein that plays a role in intercellular and intracellular signaling, inflammation, and differentiation. Our aim was to evaluate the stathmin-2 level and its relationship with the metabolic parameters of newly diagnosed type 2 diabetes mellitus (nT2DM) patients.
This case-control study included 76 patients with nT2DM and 76 healthy individuals with a normal oral glucose tolerance test who were matched for body mass index (BMI), age, and gender. In addition to laboratory and anthropometric measurements related to type 2 diabetes mellitus (T2DM), stathmin-2 levels were determined using an enzyme-linked immunosorbent assay.
We observed significantly higher circulating stathmin-2 levels in subjects with T2DM compared to the control group (6.39±1.60 ng/mL and 4.66±0.80 ng/mL, p<0.0001). In patients with metabolic syndrome, circulating stathmin-2 levels were significantly elevated compared to those without metabolic syndrome in both the T2DM and control groups (T2DM: 7.16±1.24 vs 5.06±1.24 ng/mL, p<0.001; Control: 3.84±1.40 vs 3.82±1.40 ng/mL). In both groups, we observed a positive correlation between stathmin-2 levels and BMI and circumference. Moreover, stathmin-2 showed a positive correlation with high-sensitivity C-reactive protein (hs-CRP), homeostatic model assessment of insulin resistance, insulin, fasting blood glucose, hemoglobin A1c, BMI, low-density lipoprotein cholesterol, and total cholesterol. A negative correlation was observed with stathmin-2 and high-density lipoprotein cholesterol. Stathmin-2 did not show any correlation with age, triglyceride, and lactate dehydrogenase.
Stathmin-2 levels were found to be elevated in patients with nT2DM and exhibited positive correlations with hyperinsulinaemia, hyperglycaemia, HOMO-IR and hs-CRP levels. These results indicate that stathmin-2 may play a role in T2DM pathogenesis.
Stathmin 是一种磷酸化蛋白，在细胞间和细胞内信号转导、炎症和分化中发挥作用。我们的目的是评估新诊断的 2 型糖尿病（nT2DM）患者的 stathmin-2 水平及其与代谢参数的关系。
这项病例对照研究纳入了 76 例 nT2DM 患者和 76 例糖耐量正常的健康个体，这些个体在体重指数（BMI）、年龄和性别方面与 T2DM 相匹配。除了与 2 型糖尿病（T2DM）相关的实验室和人体测量学测量外，还使用酶联免疫吸附试验测定了 stathmin-2 水平。
我们观察到 T2DM 组患者的循环 stathmin-2 水平明显高于对照组（6.39±1.60ng/ml 和 4.66±0.80ng/ml，p<0.0001）。在代谢综合征患者中，T2DM 和对照组中循环 stathmin-2 水平在患有代谢综合征的患者中明显高于没有代谢综合征的患者（T2DM：7.16±1.24 vs 5.06±1.24ng/ml，p<0.001；对照组：3.84±1.40 vs 3.82±1.40ng/ml）。在两组中，我们观察到 stathmin-2 水平与 BMI 和腰围呈正相关。此外，stathmin-2 与高敏 C 反应蛋白（hs-CRP）、稳态模型评估的胰岛素抵抗、胰岛素、空腹血糖、糖化血红蛋白、BMI、低密度脂蛋白胆固醇和总胆固醇呈正相关。stathmin-2 与高密度脂蛋白胆固醇呈负相关。stathmin-2 与年龄、三酰甘油和乳酸脱氢酶无相关性。
我们发现 nT2DM 患者的 stathmin-2 水平升高，并与高胰岛素血症、高血糖、HOMA-IR 和 hs-CRP 水平呈正相关。这些结果表明，stathmin-2 可能在 T2DM 的发病机制中发挥作用。
