Division of Endocrinology and Metabolism, Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey.
Department of Internal Medicine, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey.
J Diabetes. 2020 Jun;12(6):474-482. doi: 10.1111/1753-0407.13020. Epub 2020 Jan 13.
Urocortin 3 (UCN3) is a peptide hormone playing a pivotal role in glucose and lipid metabolisms. However, its clinical implications remain unclear. Our aims were to investigate the altered levels of UCN3 in newly diagnosed type 2 diabetes mellitus (nT2DM) patients in comparison to subjects with normal glucose tolerance (NGT) and to determine the presence of any possible link between UCN3 levels and metabolic parameters.
Eighty nT2DM and 80 age-, body mass index (BMI)-, and gender-matched NGT subjects were enrolled into this case-control study. The circulating UCN3 levels were measured using the enzyme-linked immunoabsorbent assay (ELISA). Metabolic parameters of enrolled subjects were also determined. A standard 75-g 2-hour oral glucose tolerance test was used for diagnosis of type 2 diabetes mellitus (T2DM).
UCN3 levels were higher in subjects with nT2DM than in controls (115.64 ± 39.26 vs 86.16 ± 22.81 pg/mL, P < .001). UCN3 levels were increased in subjects with metabolic syndrome compared to subjects without metabolic syndrome in both nT2DM and NGT groups. UCN3 levels showed a positive correlation with BMI in both groups. Moreover, UCN3 levels were positively and independently associated with insulin, fasting blood glucose, insulin resistance, 2-hour plasma glucose, glycosylated hemoglobin, and triglycerides, whereas UCN3 levels were negatively and independently associated with high-density lipoprotein cholesterol. According to logistic regression analysis, increased risk of T2DM and metabolic syndrome were parallel with the highest elevated levels of UCN3.
Increased levels of UCN3 are associated with unfavorable metabolic profiles in T2DM, indicating a potential role of UCN3 in glucose and lipid metabolisms in T2DM.
孤啡肽 3（UCN3）是一种在糖脂代谢中起关键作用的肽类激素。然而，其临床意义尚不清楚。我们的目的是研究新诊断的 2 型糖尿病（nT2DM）患者与血糖正常的糖耐量（NGT）患者相比 UCN3 水平的变化，并确定 UCN3 水平与代谢参数之间是否存在任何可能的联系。
本病例对照研究纳入了 80 名 nT2DM 患者和 80 名年龄、体重指数（BMI）和性别匹配的 NGT 受试者。采用酶联免疫吸附试验（ELISA）测定循环 UCN3 水平。还测定了纳入受试者的代谢参数。标准的 75g 2 小时口服葡萄糖耐量试验用于诊断 2 型糖尿病（T2DM）。
与对照组相比，nT2DM 患者的 UCN3 水平更高（115.64±39.26 与 86.16±22.81pg/ml，P<0.001）。与无代谢综合征的受试者相比，nT2DM 和 NGT 组中代谢综合征患者的 UCN3 水平升高。UCN3 水平与两组中的 BMI 呈正相关。此外，UCN3 水平与胰岛素、空腹血糖、胰岛素抵抗、2 小时血糖、糖化血红蛋白和甘油三酯呈正相关，而与高密度脂蛋白胆固醇呈负相关。根据逻辑回归分析，T2DM 和代谢综合征的风险增加与 UCN3 水平的最高升高平行。
UCN3 水平升高与 T2DM 患者的不良代谢特征相关，表明 UCN3 在 T2DM 的糖脂代谢中具有潜在作用。
