Department of Ultrasound, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.
Department of Ultrasound, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.
Ultrasound Med Biol. 2024 Jun;50(6):954-960. doi: 10.1016/j.ultrasmedbio.2024.03.003. Epub 2024 Apr 4.
The purpose of this study was to retrospectively analyze the characteristics of contrast-enhanced ultrasound (CEUS) images and quantitative parameters of time-intensity curves (TICs) in children's peripheral neuroblastic tumors (pNTs). By comparing the imaging features and quantitative parameters of the TICs of neuroblastoma (NB) and ganglioneuroblastoma (GNB) patients, we attempted to identify the distinguishing points between NB and GNB. A total of 35 patients confirmed to have pNTs by pathologic examination were included in this study. Each child underwent CEUS with complete imaging data (including still images and at least 3 min of video files). Twenty-four patients were confirmed to have NB, and 11 were considered to have GNB according to differentiation. The CEUS image features and quantitative parameters of the TICs of all lesions were analyzed to determine whether there were CEUS-related differences between the two types of pNT. There was a significant difference in the enhancement patterns of the CEUS features (χ = 5.303, p < 0.05), with more "peripheral-central" enhancement in the NB group and more "central-peripheral" enhancement in the GNB group. In the TIC, the rise time and time to peak were significantly different (p < 0.05). The receiver operating characteristic curve showed that the probability of ganglion cell NB increased significantly after RT > 15.29, with a sensitivity of 0.636 and a specificity of 0.958. When the peak time was greater than 16.155, the probability of NB increased significantly, with a sensitivity of 0.636 and a specificity of 0.958. The CEUS features of NB and GNB patients are very similar, and it is difficult to distinguish them. Rise time and time to peak may be useful in identifying GNB and NB, but the sample size of this study was small, and the investigation was only preliminary; a larger sample size is needed to support these conclusions.
本研究旨在回顾性分析儿童外周神经母细胞瘤（pNT）的超声造影（CEUS）图像特征和时间强度曲线（TIC）定量参数。通过比较神经母细胞瘤（NB）和神经节母细胞瘤（GNB）患者的成像特征和 TIC 定量参数，试图确定 NB 和 GNB 之间的鉴别点。本研究共纳入 35 例经病理检查证实为 pNT 的患者。每位患儿均行 CEUS 检查，且具有完整的影像学资料（包括静态图像和至少 3 分钟的视频文件）。24 例患儿被确认为 NB，11 例患儿根据分化程度被认为是 GNB。分析所有病灶的 CEUS 图像特征和 TIC 定量参数，以确定两种类型的 pNT 是否存在与 CEUS 相关的差异。CEUS 特征的增强模式有显著差异（χ=5.303，p<0.05），NB 组以“外周-中央”增强为主，GNB 组以“中央-外周”增强为主。在 TIC 中，上升时间和达峰时间有显著差异（p<0.05）。受试者工作特征曲线显示，RT>15.29 时，神经节细胞 NB 的发生概率显著增加，灵敏度为 0.636，特异性为 0.958。当达峰时间大于 16.155 时，NB 的发生概率显著增加，灵敏度为 0.636，特异性为 0.958。NB 和 GNB 患者的 CEUS 特征非常相似，难以区分。上升时间和达峰时间可能有助于鉴别 GNB 和 NB，但本研究的样本量较小，调查仅为初步研究；需要更大的样本量来支持这些结论。
