Ali Ehsan Sayed, Yalın Ali Erdinç, Yalın Serap
Department of Biochemistry, Faculty of Pharmacy, Mersin University, Mersin, Turkey.
Nucleosides Nucleotides Nucleic Acids. 2025;44(2):170-184. doi: 10.1080/15257770.2024.2336210. Epub 2024 Apr 4.
Cancer is still one of the most important diseases that have a high mortality rate around the world. The management of cancer involves many procedures, which include surgery, radiotherapy, and chemotherapy. Drug resistance in cancer chemotherapy is considered one of the most important problems in clinical oncology. A good understanding of the tumorigenesis process and the mechanisms of developing chemotherapy resistance in cancer cells will help achieve significant advances in cancer treatment protocols. In recent years, there has been an increasing interest in long noncoding RNAs (lncRNAs). LncRNAs are no longer just a transcriptional noise, and many investigations proved their possible roles in regulating mandatory cellular functions. A lot of newly published studies confirmed the implication of lncRNAs in the tumor formation process and the multiple drug resistance in cancer chemotherapy. The main aim of this review is to focus on the lncRNAs' functions in the cell, their possible roles in the tumor formation process, and their roles in the development of chemotherapy resistance in different cancer cells.
癌症仍然是全球死亡率很高的最重要疾病之一。癌症的治疗涉及许多程序，包括手术、放疗和化疗。癌症化疗中的耐药性被认为是临床肿瘤学中最重要的问题之一。深入了解肿瘤发生过程以及癌细胞产生化疗耐药性的机制，将有助于在癌症治疗方案上取得重大进展。近年来，人们对长链非编码RNA（lncRNAs）的兴趣与日俱增。lncRNAs不再仅仅是转录噪音，许多研究证明它们在调节细胞必需功能方面可能发挥作用。许多新发表的研究证实了lncRNAs在肿瘤形成过程和癌症化疗多药耐药性中的作用。本综述的主要目的是关注lncRNAs在细胞中的功能、它们在肿瘤形成过程中的可能作用以及它们在不同癌细胞化疗耐药性发展中的作用。
