长非编码 RNA 调控癌症的药物耐药性。
Long non-coding RNAs regulate drug resistance in cancer.
机构信息
The First Affiliated Hospital of Southern University of Science and Technology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, 518020, Guangdong, People's Republic of China.
Department of Physics, Technical University of Munich, 85748, Garching, Germany.
出版信息
Mol Cancer. 2020 Mar 12;19(1):54. doi: 10.1186/s12943-020-01162-0.
Chemoresistance, whether intrinsic or acquired, is a major obstacle in the treatment of cancer. The resistance of cancer cells to chemotherapeutic drugs can result from various mechanisms. Over the last decade, it has been reported that 1ong noncoding RNAs (lncRNAs) can mediate carcinogenesis and drug resistance/sensitivity in cancer cells. This article reviews, in detail, recent studies regarding the roles of lncRNAs in mediating drug resistance.
化疗耐药性（无论是内在的还是获得性的）是癌症治疗的主要障碍。癌细胞对化疗药物的耐药性可能源于多种机制。在过去的十年中，已有报道称长链非编码 RNA（lncRNA）可介导癌细胞的癌变和耐药性/敏感性。本文详细综述了 lncRNA 介导耐药性的最新研究进展。
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