Asribekova M K, Karpova S K, Astakhova T M
Probl Endokrinol (Mosk). 1985 Mar-Apr;31(2):26-9.
A study was made of the content of estrogen and progesterone receptors (ER and PR, respectively) in the cytosol and nuclei of the decidual tissue of women in induced and spontaneous abortion at 7-12 week pregnancy. Abortion was done surgically (control group) and in preliminary cervical dilatation with the help of intravaginal suppositories with a synthetic prostaglandin analog of E1-16.16-dimethyltrans-delta 2-PGE1 (ONO-802) group or laminaria. The level of ER in the cytosol and nuclei of the decidual tissue of the control group was twice as low as that of PR, and the ER/PR ratio in cell fractions as well as in general cell receptors was 0.58 +/- 0.09, 0.42 +/- 0.07 and 0.56 +/- 0.07, respectively. The suppositories with ONO-802 caused a statistically significant decrease in the PR content in each of the cell fractions and cytoplasmic ER resulting in an increase in the ER/PR ratio to 0.87 +/- 0.06 (P less than 0.05) in the cytosol, 0.09 +/- 0.24 (P less than 0.05) in the nuclei, and 0.86 +/- 0.8 (P less than 0.05) in the total cell. A decrease in the PR level in both cell fractions and the ER level in the fraction of the nuclei with an acute increase in the content of cytoplasmic ER was marked in spontaneous abortion. The ER/PR ratio also rose to ER and was 1.98 +/- +/- 0.2 (P less than 0.001) in the cytosol and 1.02 +/- 0.16 (P less than 0.05) in the total cell. It was concluded that an absolute and/or relative decrease in the PR level plays an important role in mechanism of abortion.
对妊娠7 - 12周人工流产和自然流产女性蜕膜组织的胞浆和细胞核中雌激素受体（ER）和孕激素受体（PR）的含量进行了研究。流产采用手术方式（对照组），以及在阴道内放置含E1 - 16.16 - 二甲基反式 - δ2 - PGE1（ONO - 802）的合成前列腺素类似物栓剂或海藻棒进行宫颈预处理（实验组）。对照组蜕膜组织胞浆和细胞核中的ER水平是PR的一半，细胞组分以及总细胞受体中的ER/PR比值分别为0.58±0.09、0.42±0.07和0.56±0.07。含ONO - 802的栓剂使各细胞组分中的PR含量以及胞浆ER含量在统计学上显著降低，导致胞浆中ER/PR比值升至0.87±0.06（P＜0.05），细胞核中为0.09±0.24（P＜0.05），总细胞中为0.86±0.8（P＜0.05）。自然流产时，细胞组分中的PR水平降低，细胞核组分中的ER水平降低，同时胞浆ER含量急剧增加。ER/PR比值也升高，胞浆中为1.98±0.2（P＜0.001），总细胞中为1.02±0.16（P＜0.05）。研究得出结论，PR水平的绝对和/或相对降低在流产机制中起重要作用。
