Kolipaka Rushil, Magesh Induja, Bharathy M R Ashok, Karthik S, Saranya I, Selvamurugan N
Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, 603203, Tamil Nadu, India.
Noncoding RNA Res. 2024 Feb 27;9(3):687-694. doi: 10.1016/j.ncrna.2024.02.018. eCollection 2024 Sep.
Cells produce short single-stranded non-coding RNAs (ncRNAs) called microRNAs (miRNAs), which actively regulate gene expression at the posttranscriptional level. Several miRNAs have been observed to exert significant impacts on bone health and bone-related disorders. One of these, miR-124, is observed in bone microenvironments and is conserved across species. It affects bone cell growth and differentiation by activating different transcription factors and signaling pathways. In-depth functional analyses of miR-124 have revealed several physiological and pathological roles exerted through interactions with other ncRNAs. Deciphering these RNA-mediated signaling networks and pathways is essential for understanding the potential impacts of dysregulated miRNA functions on bone biology. In this review, we aim to provide a comprehensive analysis of miR-124's involvement in bone physiology and pathology. We highlight the importance of miR-124 in controlling transcription factors and signaling pathways that promote bone growth. This review reveals therapeutic implications for the treatment of bone-related diseases.
细胞会产生名为微小RNA（miRNA）的短单链非编码RNA（ncRNA），其在转录后水平积极调控基因表达。已观察到几种miRNA对骨骼健康和骨骼相关疾病产生重大影响。其中之一，即miR - 124，在骨微环境中被观察到且在物种间保守。它通过激活不同的转录因子和信号通路来影响骨细胞的生长和分化。对miR - 124的深入功能分析揭示了其通过与其他ncRNA相互作用发挥的几种生理和病理作用。解读这些RNA介导的信号网络和通路对于理解miRNA功能失调对骨生物学的潜在影响至关重要。在本综述中，我们旨在全面分析miR - 124在骨生理学和病理学中的作用。我们强调了miR - 124在控制促进骨生长的转录因子和信号通路方面的重要性。本综述揭示了其在治疗骨骼相关疾病方面的潜在应用。
