阿普米拉斯对伴有掌跖外症状的重度掌跖脓疱病可能是一种有效的治疗方法。
Apremilast is a potentially useful treatment for severe palmoplantar pustulosis with extra-palmoplantar symptoms.
作者信息
Fukushima-Nomura Ayano, Takamiyagi Saeko, Kakuta Risa, Ito Yoshihiro, Hirai Ikuko, Umemoto Junichi, Hanaoka Hironari, Kaneko Yuko, Tanese Keiji
机构信息
Department of Dermatology Keio University School of Medicine Tokyo Japan.
Horinouchi-ekimae Dermatology Clinic Yokohama Japan.
出版信息
Skin Health Dis. 2024 Jan 15;4(2):e336. doi: 10.1002/ski2.336. eCollection 2024 Apr.
Palmoplantar pustulosis (PPP) is a chronic inflammatory skin disorder affecting the palms and soles. In rare cases, severe patients develop acute extra-palmoplantar lesions often accompanied by arthralgia. Such cases with extensive symptoms often necessitate systemic treatments with variable efficacy and potential side effects. Apremilast, known for its broad immune response modulation, presents promise as a therapeutic option for severe PPP with joint and extra-palmoplantar lesions. This case highlights apremilast as a potential systemic treatment for such cases with minimal side effects.
掌跖脓疱病（PPP）是一种影响手掌和脚底的慢性炎症性皮肤病。在罕见情况下，严重患者会出现急性掌跖外病变，常伴有关节痛。这类有广泛症状的病例通常需要进行全身治疗，但疗效各异且有潜在副作用。阿普米司特以其广泛的免疫反应调节作用而闻名，有望成为治疗伴有关节和掌跖外病变的重度PPP的一种治疗选择。本病例突出了阿普米司特作为此类病例潜在全身治疗方法且副作用最小的特点。
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