Wang Rui-Ni, Zhang Ping-Shun, Zhu Xiao-Fang
Department of Dermatology of Dingbian County Hospital Shanxi China.
Department of Dermatology of Clinical Medical college of Yangzhou University Jiangsu China.
Skin Health Dis. 2024 Jan 27;4(2):e344. doi: 10.1002/ski2.344. eCollection 2024 Apr.
Hyperkeratosis of the nipples and areolae (HNA) is an uncommon skin disorder with no definite aetiology. We report a case of a 16-year-old boy, who presented with bilateral pigmentation and thickening of the nipples and areolae, accompanied with linear brown protrusions on the anterior neck and a velvet like appearance with pigmentation on the axillary bilaterlly. Based on clinical and histopathological, and dermatoscopic findings, the diagnosis of bilateral HNA accompanied by linear nevus and acanthosis nigricans was made. The skin lesions were improved by treatment with topical calcipotriol gel.
乳头和乳晕角化过度(HNA)是一种病因不明的罕见皮肤疾病。我们报告一例16岁男孩病例,其双侧乳头和乳晕色素沉着且增厚,同时前颈部有线性褐色突起,双侧腋窝呈天鹅绒样外观并伴有色素沉着。根据临床、组织病理学及皮肤镜检查结果,诊断为双侧HNA伴线性痣和黑棘皮病。经外用卡泊三醇凝胶治疗后,皮肤病变有所改善。