Wang Mei-Fang, Wang Li, Li Lin-Feng
a Beijing Friendship Hospital , Capital Medical University , Beijing , China.
Postgrad Med. 2018 Apr;130(3):361-364. doi: 10.1080/00325481.2018.1446652. Epub 2018 Mar 5.
Hyperkeratosis of the nipple and areola is an uncommon dermatosis without well-defined etiology, which occurs mostly in young women and may only be a cosmetic problem. In 1938, Levy-Frankel classified this disease into three variants; type I involves hyperkeratosis with an epidermal nevus, and has rarely been reported. We report a case of a 23-year-old woman with long-term bilateral pigmentation and thickening of the nipples and areolae, accompanied with dark brown, flat lesions with a linear distribution on her left forearm. The verrucous plaques were asymptomatic and could be scratched off by the patient herself. Consequently, she did not seek medical care for more than ten years. The prevalence of this condition is likely underestimated because many affected individuals are not sufficiently motivated to seek medical attention.
乳头和乳晕角化过度是一种病因不明的罕见皮肤病，多见于年轻女性，可能仅是一个美容问题。1938年，Levy-Frankel将此病分为三种类型；I型伴有表皮痣的角化过度，鲜有报道。我们报告一例23岁女性病例，其双侧乳头和乳晕长期色素沉着且增厚，左前臂有呈线状分布的深褐色扁平皮损。疣状斑块无症状，患者自己可以刮除。因此，她十多年来都未就医。由于许多患者没有足够的动力寻求医疗关注，这种疾病的患病率可能被低估了。
