Pinto G L, Meyer D R
Department of Ophthalmology, Albany Medical College, New York 12208.
Ophthalmic Plast Reconstr Surg. 1994 Mar;10(1):49-50. doi: 10.1097/00002341-199403000-00010.
A 77-year-old man had fleshy papillomatous lesions on his eyelid margins, which initially were accompanied by lesions on his lips and tongue and plaques on his scrotum, areolae, neck, axillae, and hands. He had had adenocarcinoma of the sigmoid colon and stomach. Based on the clinical findings and histopathologic evaluation of the eyelids (showing papillomatous changes with hyperkeratosis and mild acanthosis), the diagnosis of acanthosis nigricans was made. Acanthosis nigricans may be benign or malignant; in this patient it was malignant. The malignant form is usually of gastrointestinal origin, and in adults may be a marker for an occult malignancy.
一名77岁男性的眼睑边缘出现肉质乳头状病变，最初伴有嘴唇、舌头的病变以及阴囊、乳晕、颈部、腋窝和手部的斑块。他曾患乙状结肠癌和胃癌。根据眼睑的临床表现和组织病理学评估（显示乳头瘤样改变伴角化过度和轻度棘皮症），诊断为黑棘皮病。黑棘皮病可能是良性或恶性的；该患者的是恶性的。恶性形式通常起源于胃肠道，在成年人中可能是隐匿性恶性肿瘤的一个标志。
