Ismail Muhammad, Ahmad Rashid, Halim Sobia Ahsan, Khan Adnan Ali, Ullah Saeed, Latif Abdul, Ahmad Manzoor, Khan Ajmal, Ozdemir Fethi Ahmet, Khalid Asaad, Al-Harrasi Ahmed, Ali Mumtaz
Department of Chemistry, University of Malakand P.O. Box 18800 Dir Lower Khyber Pakhtunkhwa Pakistan
Central for Computational Materials Science P.O. Box 18800 Dir Lower Khyber Pakhtunkhwa Pakistan.
RSC Adv. 2024 Apr 4;14(16):10978-10994. doi: 10.1039/d4ra00045e. eCollection 2024 Apr 3.
In recent years, polyhydroquinolines have gained much attention due to their widespread applications in medicine, agriculture, industry, Here, we synthesized a series of novel hydrazone-based polyhydroquinoline derivatives multi-step reactions. These molecules were characterized by modern spectroscopic techniques (H-NMR, C NMR, and LC-HRMS) and their antibacterial and α-glucosidase inhibitory activities were assessed. Compound 8 was found to be the most active inhibitor against NCTC 5348, IM 622, , and ATCC 6337 with a zone of inhibition of 15.3 ± 0.01, 13.2 ± 0.2, 13.1 ± 0.1, and 12.6 ± 0.3 mm, respectively. Likewise, compound 8 also exhibited the most potent inhibitory potential for α-glucosidase (IC = 5.31 ± 0.25 μM) , followed by compounds 10 (IC = 6.70 ± 0.38 μM), and 12 (IC = 6.51 ± 0.37 μM). Furthermore, molecular docking and DFT analysis of these compounds showed good agreement with experimental work and the nonlinear optical properties calculated here indicate that these compounds are good candidates for nonlinear optics.
近年来，多羟基喹啉因其在医药、农业、工业等领域的广泛应用而备受关注。在此，我们通过多步反应合成了一系列新型的腙基多羟基喹啉衍生物。这些分子通过现代光谱技术（氢核磁共振、碳核磁共振和液相色谱-高分辨质谱）进行了表征，并评估了它们的抗菌和α-葡萄糖苷酶抑制活性。发现化合物8是对NCTC 5348、IM 622和ATCC 6337最具活性的抑制剂，其抑菌圈分别为15.3±0.01、13.2±0.2、13.1±0.1和12.6±0.3毫米。同样，化合物8对α-葡萄糖苷酶也表现出最有效的抑制潜力（IC = 5.31±0.25微摩尔），其次是化合物10（IC = 6.70±0.38微摩尔）和12（IC = 6.51±0.37微摩尔）。此外，这些化合物的分子对接和密度泛函理论分析与实验工作显示出良好的一致性，此处计算的非线性光学性质表明这些化合物是非线性光学的良好候选物。
