Synthesis of hydrazone-based polyhydroquinoline derivatives - antibacterial activities, α-glucosidase inhibitory capability, and DFT study.

In recent years, polyhydroquinolines have gained much attention due to their widespread applications in medicine, agriculture, industry, Here, we synthesized a series of novel hydrazone-based polyhydroquinoline derivatives multi-step reactions. These molecules were characterized by modern spectroscopic techniques (H-NMR, C NMR, and LC-HRMS) and their antibacterial and α-glucosidase inhibitory activities were assessed. Compound 8 was found to be the most active inhibitor against NCTC 5348, IM 622, , and ATCC 6337 with a zone of inhibition of 15.3 ± 0.01, 13.2 ± 0.2, 13.1 ± 0.1, and 12.6 ± 0.3 mm, respectively. Likewise, compound 8 also exhibited the most potent inhibitory potential for α-glucosidase (IC = 5.31 ± 0.25 μM) , followed by compounds 10 (IC = 6.70 ± 0.38 μM), and 12 (IC = 6.51 ± 0.37 μM). Furthermore, molecular docking and DFT analysis of these compounds showed good agreement with experimental work and the nonlinear optical properties calculated here indicate that these compounds are good candidates for nonlinear optics.