Awad Kamal, Ahuja Neelam, Yacoub Ahmed S, Brotto Leticia, Young Simon, Mikos Antonios, Aswath Pranesh, Varanasi Venu
Bone Muscle Research Center, College of Nursing and Health Innovations, University of Texas at Arlington, Arlington, TX, United States.
Department of Materials Science and Engineering, College of Engineering, The University of Texas at Arlington, Arlington, TX, United States.
Front Aging. 2023 Jul 14;4:1217054. doi: 10.3389/fragi.2023.1217054. eCollection 2023.
In this review, we explore the application of novel biomaterial-based therapies specifically targeted towards craniofacial bone defects. The repair and regeneration of critical sized bone defects in the craniofacial region requires the use of bioactive materials to stabilize and expedite the healing process. However, the existing clinical approaches face challenges in effectively treating complex craniofacial bone defects, including issues such as oxidative stress, inflammation, and soft tissue loss. Given that a significant portion of individuals affected by traumatic bone defects in the craniofacial area belong to the aging population, there is an urgent need for innovative biomaterials to address the declining rate of new bone formation associated with age-related changes in the skeletal system. This article emphasizes the importance of semiconductor industry-derived materials as a potential solution to combat oxidative stress and address the challenges associated with aging bone. Furthermore, we discuss various material and autologous treatment approaches, as well as and models used to investigate new therapeutic strategies in the context of craniofacial bone repair. By focusing on these aspects, we aim to shed light on the potential of advanced biomaterials to overcome the limitations of current treatments and pave the way for more effective and efficient therapeutic interventions for craniofacial bone defects.
在本综述中，我们探讨了专门针对颅面骨缺损的新型生物材料疗法的应用。颅面区域临界尺寸骨缺损的修复和再生需要使用生物活性材料来稳定并加速愈合过程。然而，现有的临床方法在有效治疗复杂的颅面骨缺损方面面临挑战，包括氧化应激、炎症和软组织损失等问题。鉴于受颅面区域创伤性骨缺损影响的个体中有很大一部分属于老龄人口，迫切需要创新的生物材料来解决与骨骼系统年龄相关变化相关的新骨形成率下降问题。本文强调了半导体行业衍生材料作为对抗氧化应激和解决与老龄骨相关挑战的潜在解决方案的重要性。此外，我们讨论了各种材料和自体治疗方法，以及用于研究颅面骨修复背景下新治疗策略的模型。通过关注这些方面，我们旨在阐明先进生物材料克服当前治疗局限性的潜力，并为更有效和高效的颅面骨缺损治疗干预铺平道路。
