St. Joseph's University Medical Center, Paterson, NJ, USA.
St. George's University School of Medicine, Grenada, West Indies.
J Investig Med High Impact Case Rep. 2024 Jan-Dec;12:23247096241242237. doi: 10.1177/23247096241242237.
Plasmacytoma is a rare plasma cell dyscrasia that grows in bones or soft tissues such as the pharynx. Soft tissue plasmacytomas are rare, and a higher burden has been reported in the upper aero-digestive tract, often manifesting as hoarseness, dysphagia, or odynophagia. Due to their rarity, extramedullary plasmacytomas (EMPs) have unknown prognostic factors, and guidelines for optimal management are still lacking. However, radiation therapy and surgery have been used with positive outcomes. Herein, we describe a unique case of plasmacytoma of the pharyngeal tissue in a male patient with a history of HIV disease. The patient completed 28 sessions of radiation therapy, resulting in an improvement in his throat pain and hoarseness. Given the patient's age and lack of traditional risk factors for head and neck cancers, his hoarseness and odynophagia proved to be a diagnostic conundrum. Although infrequent, soft tissue plasmacytomas should be considered in the differential diagnosis of head and neck tumors.
浆细胞瘤是一种罕见的浆细胞异常增生，生长在骨骼或软组织中，如咽。软组织浆细胞瘤较为罕见，在上呼吸道-消化道的负担较高，常表现为声音嘶哑、吞咽困难或吞咽疼痛。由于其罕见性，髓外浆细胞瘤（EMP）的预后因素未知，且缺乏最佳管理的指南。然而，放射治疗和手术已被证明有积极的效果。在此，我们描述了一名 HIV 病史男性患者咽组织浆细胞瘤的独特病例。患者完成了 28 次放射治疗，其喉咙痛和声音嘶哑得到改善。鉴于患者的年龄和缺乏头颈部癌症的传统危险因素，他的声音嘶哑和吞咽疼痛被证明是一个诊断难题。尽管不常见，但在头颈部肿瘤的鉴别诊断中应考虑软组织浆细胞瘤。
