Ben Shalom Dorit, Skandalakis Georgios P
School of Brain Sciences and Cognition, Ben-Gurion University of the Negev, Beersheba, Israel.
Section of Neurosurgery, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA.
Neuroscientist. 2025 Feb;31(1):8-13. doi: 10.1177/10738584241245304. Epub 2024 Apr 5.
Merging functional evidence derived from studies of autism spectrum disorder and attention-deficit/hyperactivity disorder converges in four neural streams of the prefrontal cortex, hence suggesting a model of information processing through four streams: motor through Brodmann area (BA) 8, emotion through BA 9, memory through BA 10, and emotional-related sensory through BA 11. A growing body of functional data has been supporting this model of information processing. Nevertheless, the underlying structural connectivity was only recently unveiled by a population-based high-definition tractography study with data from 1,065 individuals. This update provides a brief overview of recent evidence supporting the anatomofunctional integration of the four streams of the prefrontal cortex and reviews the white matter fiber tracts subserving the four streams.
自闭症谱系障碍和注意力缺陷多动障碍研究得出的功能证据在额叶前皮质的四条神经通路中汇聚，因此提出了一种通过四条通路进行信息处理的模型：通过布罗德曼区（BA）8进行运动控制，通过BA 9处理情绪，通过BA 10处理记忆，以及通过BA 11处理与情绪相关的感觉。越来越多的功能数据支持这种信息处理模型。然而，基于人群的高清纤维束成像研究利用1065名个体的数据，才刚刚揭示了其潜在的结构连通性。本综述简要概述了支持额叶前皮质四条神经通路解剖功能整合的最新证据，并回顾了服务于这四条神经通路的白质纤维束。
